Journal ArticleDOI
Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire: a randomised trial
Stefan Z. Wiktor,Ehounou R. Ekpini,John M. Karon,John N. Nkengasong,Chantal Maurice,Sibailly T Severin,Thierry H. Roels,Moïse K Kouassi,Eve M. Lackritz,Issa-Malick Coulibaly,Alan E. Greenberg +10 more
Reads0
Chats0
TLDR
Short-course oral zidovudine was safe, well tolerated, and decreased mother-to-child transmission of HIV-1 at age 3 months, and substantial efforts will be needed to ensure successful widespread implementation of such a regimen.About:
This article is published in The Lancet.The article was published on 1999-03-06. It has received 557 citations till now. The article focuses on the topics: Regimen & Population.read more
Citations
More filters
Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
TL;DR: Nevirapine lowered the risk of HIV-1 transmission during the first 14-16 weeks of life by nearly 50% in a breastfeeding population, suggesting this simple and inexpensive regimen could decrease mother-to-child HIV- 1 transmission in less-developed countries.
Journal ArticleDOI
Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis
Marie-Louise Newell,Hoosen M. Coovadia,Marjo Cortina-Borja,Nigel Rollins,Philippe Gaillard,François Dabis +5 more
TL;DR: Findings highlight the necessity for timely antiretroviral care for support for HIV-infected women and children in developing countries, and for assessment of prophylactic programmes to prevent MTCT, including child mortality and infection averted.
Journal ArticleDOI
Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice.
Kevin M. De Cock,Mary Glenn Fowler,Eric Mercier,Isabelle de Vincenzi,Joseph Saba,Elizabeth Hoff,David J. Alnwick,Martha F. Rogers,Nathan Shaffer +8 more
TL;DR: Current knowledge of mother-to-child HIV transmission in developing countries is reviewed, key findings from the trials are summarized, future research requirements are outlined, and public health challenges of implementing perinatal HIV prevention interventions in resource-poor settings are described.
Journal ArticleDOI
The burden of malaria in pregnancy in malaria-endemic areas.
TL;DR: It is estimated that each year 75,000 to 200,000 infant deaths are associated with malaria infection in pregnancy and the failure to apply known effective antimalarial interventions through antenatal programs continues to contribute substantially to infant deaths globally.
Journal ArticleDOI
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial
J. Brooks Jackson,Philippa Musoke,Thomas Fleming,Thomas Fleming,Laura Guay,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Maxensia Owor,Constance Ducar,Martina Deseyve,Anthony Mwatha,Lynda Emel,Corey Duefield,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Maria Gigliotti,Dorothy Bray,Francis Mmiro +22 more
TL;DR: Intrapartum/ne ononatal nevirapine significantly lowered HIV-1 transmission risk in a breastfeeding population in Uganda compared with a short intrapartu/neonatal zidovudine regimen.
References
More filters
Book
Discrete multivariate analysis: theory and practice
TL;DR: Discrete Multivariate Analysis is a comprehensive text and general reference on the analysis of discrete multivariate data, particularly in the form of multidimensional tables, and contains a wealth of material on important topics.
Journal Article
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
Journal ArticleDOI
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
Edward M. Connor,Rhoda S. Sperling,Richard D. Gelber,Pavel Kiselev,Gwendolyn B. Scott,Mary Jo O'Sullivan,Russell Vandyke,Mohammed Bey,William T. Shearer,Robert L. Jacobson,Eleanor Jimenez,Edward O’neill,Brigitte Bazin,Jean François Delfraissy,Mary Culnane,Robert W. Coombs,Mary Elkins,Jack Moye,Pamela Stratton,James Balsley +19 more
TL;DR: In pregnant women with mildly symptomatic HIV disease and no prior treatment with antiretroviral drugs during the pregnancy, a regimen consisting of zidovudine given ante partum and intra partum to the mother and to the newborn for six weeks reduced the risk of maternal-infant HIV transmission by approximately two thirds.
Journal ArticleDOI
Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial
Nathan Shaffer,Rutt Chuachoowong,Philip A. Mock,Chaiporn Bhadrakom,Wimol Siriwasin,Nancy L. Young,Tawee Chotpitayasunondh,Sanay Chearskul,Anuvat Roongpisuthipong,Pratharn Chinayon,John M. Karon,Timothy D. Mastro,R.J. Simonds +12 more
TL;DR: A short course of twice-daily oral zidovudine was safe and well tolerated and, in the absence of breastfeeding, can lessen the risk for mother-to-child HIV-1 transmission by half.
Journal ArticleDOI
Risk of human immunodeficiency virus type 1 transmission through breastfeeding.
TL;DR: Since breastfeeding protects against infant deaths from infectious diseases, breastfeeding is still recommended where infectious diseases are a common cause of death in childhood, despite the additional risk of HIV transmission.
Related Papers (5)
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial
Laura Guay,Philippa Musoke,Thomas Fleming,Danstan Bagenda,Melissa Allen,Clemensia Nakabiito,Joseph Sherman,Paul M Bakaki,Constance Ducar,Martina Deseyve,Lynda Emel,Mark Mirochnick,Mary Glenn Fowler,Lynne M. Mofenson,Paolo G. Miotti,Kevin Dransfield,Dorothy Bray,Francis Mmiro,J. Brooks Jackson +18 more
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
Edward M. Connor,Rhoda S. Sperling,Richard D. Gelber,Pavel Kiselev,Gwendolyn B. Scott,Mary Jo O'Sullivan,Russell Vandyke,Mohammed Bey,William T. Shearer,Robert L. Jacobson,Eleanor Jimenez,Edward O’neill,Brigitte Bazin,Jean François Delfraissy,Mary Culnane,Robert W. Coombs,Mary Elkins,Jack Moye,Pamela Stratton,James Balsley +19 more
Reduction of maternal-infant transmission of human immunodeficiency virus 1 with zidovudine treatment
Edward M. Connor,Rhoda S. Sperling,Richard D. Gelber,Pavel Kiselev,Gwendolyn B. Scott,Mary J. O'Sullivan,Russell Vandyke,Mohammed Bey,William T. Shearer,R Jacobson,Eleanor Jimenez,Edward O’neill,Brigitte Bazin,Jean François Delfraissy,Mary Culnane,Robert W. Coombs,Mary Elkins,Jack Moye,Pamela Stratton,James Balsley +19 more