Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry.
TLDR
These haplotype frequencies will be used to improve match predictions for donor selection algorithms for hematopoietic stem cell transplantation and improve the accuracy in modeling registry match rates.About:
This article is published in Human Immunology.The article was published on 2013-10-01 and is currently open access. It has received 320 citations till now. The article focuses on the topics: Donor selection & Population.read more
Citations
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Journal ArticleDOI
HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry
Loren Gragert,Mary Eapen,Eric Williams,John Freeman,Stephen R. Spellman,Robert L. Baitty,Robert J. Hartzman,J. Douglas Rizzo,Mary M. Horowitz,Dennis L. Confer,Martin Maiers +10 more
TL;DR: Most patients likely to benefit from HSCT will have a donor, with the highest probability among whites of European descent, and the lowest probability among blacks of South or Central American descent, regardless of racial and ethnic background.
Journal ArticleDOI
A large peptidome dataset improves HLA class I epitope prediction across most of the human population.
Siranush Sarkizova,Siranush Sarkizova,Susan Klaeger,Phuong M. Le,Letitia Li,Giacomo Oliveira,Hasmik Keshishian,Christina R. Hartigan,Wandi Zhang,David A. Braun,Keith L. Ligon,Pavan Bachireddy,Pavan Bachireddy,Pavan Bachireddy,Ioannis K. Zervantonakis,Jennifer M. Rosenbluth,Tamara Ouspenskaia,Travis Law,Sune Justesen,Jonathan Stevens,William J. Lane,William J. Lane,Thomas Eisenhaure,Guang Lan Zhang,Guang Lan Zhang,Karl R. Clauser,Nir Hacohen,Nir Hacohen,Steven A. Carr,Catherine J. Wu,Derin B. Keskin +30 more
TL;DR: HLAthena is developed, providing allele-and-length-specific and pan-allele-pan-length prediction models for endogenous peptide presentation that correctly identified >75% of HLA-bound peptides that were observed experimentally in 11 patient-derived tumor cell lines.
Journal ArticleDOI
Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease
Fusheng Zhou,Hongzhi Cao,Xianbo Zuo,Tao Zhang,Xiaoguang Zhang,Xiaomin Liu,Ricong Xu,Gang Chen,Yuanwei Zhang,Xiaodong Zheng,Xin Jin,Jinping Gao,Junpu Mei,Yujun Sheng,Qibin Li,Bo Liang,Juan Shen,Changbing Shen,Hui Jiang,Caihong Zhu,Xing Fan,Fengping Xu,Min Yue,Xianyong Yin,Chen Ye,Cuicui Zhang,Xiao Liu,Liang Yu,Jinghua Wu,Mengyun Chen,Xuehan Zhuang,Lili Tang,Haojing Shao,Longmao Wu,Jian Li,Yu Xu,Yijie Zhang,Suli Zhao,Yu Wang,Ge Li,Hanshi Xu,Lei Zeng,Jianan Wang,Mingzhou Bai,Yanling Chen,Wei Chen,Tian Kang,Yan-Yan Wu,Xun Xu,Zhengwei Zhu,Yong Cui,Zaixing Wang,Chun-Jun Yang,Pei-Guang Wang,Leihong Xiang,Xiang Chen,Anping Zhang,Xinghua Gao,Furen Zhang,Jinhua Xu,Min Zheng,Jie Zheng,Jianzhong Zhang,Xueqing Yu,Yingrui Li,Sen Yang,Huanming Yang,Jian Wang,Jianjun Liu,Lennart Hammarström,Liangdan Sun,Jun Wang,Xuejun Zhang +72 more
TL;DR: The entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry is sequenced and a Han-MHC database is constructed that includes both variants and HLA gene typing results of high accuracy to advance understanding of the pathogenesis of these disorders.
Journal ArticleDOI
Immunogenetics of type 1 diabetes: A comprehensive review.
TL;DR: The results of decades of small and large genetic linkage and association studies show clearly that the HLA genes confer the most disease risk and protection and can be used as part of a prediction strategy for T1D.
Journal ArticleDOI
HLA diversity in the 1000 genomes dataset.
Pierre-Antoine Gourraud,Pouya Khankhanian,Nezih Cereb,Soo Young Yang,Michael Feolo,Martin Maiers,John D. Rioux,Stephen L. Hauser,Jorge R. Oksenberg +8 more
TL;DR: This analysis of linkage disequilibrium (LD) decay in these samples suggests that overestimation of pairwise LD occurs due to a limited sampling of the MHC diversity, and is a valuable resource for future analyses of the role of MHC in population and disease studies.
References
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