Journal ArticleDOI
Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control
Eric Féraille,Alain Doucet +1 more
TLDR
How molecular events at the transporter level account for the physiological changes in tubular handling of sodium promoted by hormones is analyzed to analyze the integrated network of signaling pathways underlying hormone action.Abstract:
Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to salt and water homeostasis The transcellular reabsorption of sodium proceeds by a two-step mechanism: read more
Citations
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Physiological basis for high CO2 tolerance in marine ectothermic animals: pre-adaptation through lifestyle and ontogeny?
Frank Melzner,Magdalena A. Gutowska,M. Langenbuch,Sam Dupont,Magnus Lucassen,Michael C. Thorndyke,Markus Bleich,Hans-Otto Pörtner +7 more
TL;DR: This paper attempts to summarize some ontogenetic and lifestyle traits that lead to an increased tolerance towards high environmental pCO2, and suggests that compensation of extracellular acid-base status in turn may be important in avoiding metabolic depression.
Journal ArticleDOI
Na+-K+ Pump Regulation and Skeletal Muscle Contractility
TL;DR: The Na+-K+ pump is a central target for regulation of Na-k+ distribution and excitability, essential for second-to-second ongoing maintenance of excitability during work.
Journal ArticleDOI
FXYD proteins: new regulators of Na-K-ATPase.
TL;DR: The results highlight the complexity of the regulation of Na+ and K+ handling by Na-K-ATPase, which is necessary to ensure appropriate tissue functions such as renal Na+ reabsorption, muscle contractility, and neuronal excitability.
Journal ArticleDOI
Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties.
TL;DR: It is demonstrated that phospholemman (PLM) (FXYD1), so far considered to be a heart- and muscle-specific channel or channel-regulating protein, associates specifically and stably with six different α-β isozymes of NKA after coexpression in Xenopus oocytes, and with α1–β, and less efficiently with α2–β iszymes, in native cardiac and skeletal muscles.
Journal ArticleDOI
Na,K-ATPase subunit heterogeneity as a mechanism for tissue-specific ion regulation.
TL;DR: The functional properties, regulation, and the biological relevance of the Na,K-ATPase isozymes as a mechanism for the tissue-specific control of Na+ and K+ homeostasis are focused on.
References
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The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
Journal ArticleDOI
Dopamine Receptors: From Structure to Function
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Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
TL;DR: All known MAPK module kinases from yeast to humans are defined, what is known about their regulation, defined MAPK substrates, and the function of MAPK in cell physiology are defined.
Journal ArticleDOI
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
TL;DR: The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions, and seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease.