Journal ArticleDOI
Solid lipid nanoparticles carrying Eugenia caryophyllata essential oil: the novel nanoparticulate systems with broad-spectrum antimicrobial activity
B.S. Fazly Bazzaz,Bahman Khameneh,Nazli Namazi,Mehrdad Iranshahi,Davood Davoodi,Shiva Golmohammadzadeh +5 more
TLDR
Solid lipid nanoparticles containing Eugenia caryophyllata essential oil were prepared by high‐shear homogenization and ultrasound methods, and used to eradicate pathogens, highlighting the effectiveness of SLN formulations against human pathogens.Abstract:
In this study, solid lipid nanoparticles containing Eugenia caryophyllata essential oil (SLN-EO) were prepared by high-shear homogenization and ultrasound methods, and used to eradicate pathogens. SLN formulations were evaluated for their size, zeta potential and encapsulation efficacy (EE). The morphological and thermal properties of the formulations were analysed by transmission electron microscopy (TEM) and differential scanning calorimetry methods. The lead formulations were chosen and tested with minimum inhibitory concentration (MIC), MBC and time-kill methods to investigate the antimicrobial activity against Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. The particle size of three final formulations were 397 ± 10·1, 786·9 ± 11 and 506·4 ± 22 nm respectively. The zeta potential of all formulations was negative values. The size of the formulations was slightly increased during 3 months storage at 25°C. The TEM imaging showed that formulation had spherical shape. The EE of EO was estimated approximately 70%. MIC and MCC values of SLN-EO were lower than those of the oil alone. The time-kill studies showed that SLN-EO was either equivalent to or better than EO (P-value <0·05). The results of this study highlighted the effectiveness of SLN formulations against human pathogens. SIGNIFICANCE AND IMPACT OF THE STUDY Microbial resistance to antibiotics is a major problem in the treatment of diseases. Therefore, overcoming antimicrobial resistance is an urgent need. Drug delivery via nanoparticles and applying natural products are promising approaches to reduce microbial resistance. This study is designed to evaluate the antimicrobial activity of solid lipid nanoparticles (SLN) containing Eugenia caryophyllata essential oil (EO) against human pathogens. The results indicated that the antimicrobial activity of EO was remarkably enhanced when encapsulated in SLN.read more
Citations
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Journal ArticleDOI
Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives.
TL;DR: Antibiotic‐free antibacterial strategies enabled by advanced nanomaterials are presented and practical antibacterial applications employing these antibiotic‐free strategies are introduced.
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Antimicrobial-loaded nanocarriers for food packaging applications.
TL;DR: Nanoencapsulation approaches provide many advantages including protection against environmental stresses, release control, and improving the solubility and absorption of natural antimicrobial agents in AP, which are the main achievements overcoming the barriers for using natural antimicrobials in food packaging.
Journal ArticleDOI
Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method
TL;DR: This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method, and summarizes recent development in SLNs or nanostructured lipid carriers production using this technique.
Journal ArticleDOI
Encapsulation strategies to enhance the antibacterial properties of essential oils in food system
TL;DR: The antibacterial effect of various essential oils can be influenced by a number of factors, such as their biologically active components and cell types as discussed by the authors, while the volatility, oxidizability, aromatic odor and insolubility are the main factors that impeding the EOs application in food industry.
Journal ArticleDOI
Recent advances in food colloidal delivery systems for essential oils and their main components
Ali Sedaghat Doost,Maryam Nikbakht Nasrabadi,Vincent Kassozi,Henriettah Nakisozi,Paul Van der Meeren +4 more
TL;DR: The current state-of-the-art in the formulation of colloidal delivery systems for food products to encapsulate EOs is reviewed and their pros and cons in terms of formulation and functionality are given.
References
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Journal ArticleDOI
Essential oils: their antibacterial properties and potential applications in foods--a review.
TL;DR: In vitro studies have demonstrated antibacterial activity of essential oils (EOs) against Listeria monocytogenes, Salmonella typhimurium, Escherichia coli O157:H7, Shigella dysenteria, Bacillus cereus and Staphylococcus aureus at levels between 0.2 and 10 microl ml(-1).
Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review.
Kamel Chaieb,Hafedh Hajlaoui,Tarek Zmantar,Amel Ben Kahla-Nakbi,Mahmoud Rouabhia,Kacem Mahdouani,Amina Bakhrouf +6 more
TL;DR: The chemical composition and biological effects of clove essential oil are addressed, and new results from GC/MS analysis and a study of its antimicrobial activity against a large number of multi‐resistant Staphylococcus epidermidis isolated from dialysis biomaterials are included.
Journal ArticleDOI
Antimicrobial applications of nanotechnology: methods and literature
Justin T. Seil,Thomas J. Webster +1 more
TL;DR: A variety of techniques to evaluate bacteria viability, each with unique advantages and disadvantages, has been established and must be understood in order to determine the effectiveness of nanoparticles (diameter ≤100 nm) as antimicrobial agents.
Journal ArticleDOI
Development of Nanoparticles for Antimicrobial Drug Delivery
TL;DR: The current progress and challenges in synthesizing nanoparticle platforms for delivering various antimicrobial drugs are reviewed and the need to unite the shared interest between nanoengineers and microbiologists in developing nanotechnology for the treatment of microbial diseases is called attention.