Journal ArticleDOI
Solid Phase Peptide Synthesis Utilizing 9-Fluorenylmethoxycarbonylamino Acids
G. B. Fields,R. L. Noble +1 more
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This article is published in ChemInform.The article was published on 1990-06-12. It has received 173 citations till now. The article focuses on the topics: Peptide synthesis.read more
Citations
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Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension.
TL;DR: It is demonstrated that it is possible to enhance the biological activity of fibrin by enzymatically incorporating exogenous oligopeptide domains of morphoregulatory proteins.
Journal ArticleDOI
Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold.
Hossein Hosseinkhani,Mohsen Hosseinkhani,Ali Khademhosseini,Ali Khademhosseini,Hisatoshi Kobayashi,Hisatoshi Kobayashi +5 more
TL;DR: It was demonstrated that the injection of an aqueous solution of PA together with BMP-2 into the back subcutis of rats, resulted in the formation of a transparent 3-D hydrogel at the injected site and induced significant homogeneous ectopic bone formation around the injected sites, in marked contrast to B MP-2 injection alone or PA injection alone.
Journal ArticleDOI
Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.
Emilie Hangen,Olivier Feraud,Olivier Feraud,Sylvie Lachkar,Haiwei Mou,Nunzianna Doti,Gian Maria Fimia,Ngoc vy Lam,Changlian Zhu,Isabelle Godin,Isabelle Godin,Isabelle Godin,Kevin Müller,Afroditi Chatzi,Esther Nuebel,Fabiola Ciccosanti,Stephane Flamant,Stephane Flamant,Paule Bénit,Paule Bénit,Jean-Luc Perfettini,Allan Sauvat,Annelise Bennaceur-Griscelli,Karine Ser-Le Roux,Karine Ser-Le Roux,Patrick Gonin,Patrick Gonin,Kostas Tokatlidis,Pierre Rustin,Pierre Rustin,Mauro Piacentini,Menotti Ruvo,Klas Blomgren,Klas Blomgren,Guido Kroemer,Nazanine Modjtahedi +35 more
TL;DR: This work has identified an AIF-interacting protein, CHCHD4, which is the central component of a redox-sensitive mitochondrial intermembrane space import machinery that contributes to the biogenesis of respiratory chain complexes and establishes an unexpected link between the vital function of AIF and the propensity of cells to undergo apoptosis.
Journal ArticleDOI
Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters.
Daniela Guarnieri,A. De Capua,Maurizio Ventre,Assunta Borzacchiello,Carlo Pedone,Daniela Marasco,Menotti Ruvo,Paolo A. Netti +7 more
TL;DR: Results suggest that cells recognize the RGD gradient and adhere onto it assuming a stretched shape, and cells tend to migrate in the direction of the gradient, as their speed is higher than that of cells migrating on hydrogels with a uniform distribution of RGD and increases by increasingRGD gradient steepness.
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Effects of the novel (Pro 3 )GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob /ob) mice: evidence that GIP is the major physiological incretin
TL;DR: Feed studies in one commonly used animal model of obesity and diabetes, (ob/ob) mice, suggest that GIP is the major physiological component of the enteroinsular axis, contributing approximately 80% to incretin-induced insulin release.
References
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Journal ArticleDOI
Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids
Gregg B. Fields,Richard L. Noble +1 more
TL;DR: The great variety of conditions under which Fmoc solid phase peptide synthesis may be carried out represents a truly "orthogonal" scheme, and thus offers many unique opportunities for bioorganic chemistry.
Related Papers (5)
Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids
Gregg B. Fields,Richard L. Noble +1 more