Journal ArticleDOI
Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone.
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TLDR
Investigation of the distribution and characterization of Sox-2 and Pax-6 in the human subventricular zone (SVZ) reveals that these TFs are differentially expressed in the adult human SVZ where Sox- 2 and Pax -6 specify a glial and neuronal fate, respectively.About:
This article is published in Experimental Neurology.The article was published on 2007-04-01. It has received 41 citations till now. The article focuses on the topics: Subventricular zone & Neurogenesis.read more
Citations
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Journal ArticleDOI
Glioblastoma stem cells: a therapeutic challenge
TL;DR: Erdoğan Pekcan ERKAN, Ufuk VURGUN, Reşat Serhat ERBAYRAKTAR, Zübeyde ERBAyraKTAR* İzmir Biomedicine and Genome Center, Dokuz Eylül University, İZmir.
Dissertation
Progenitor cells in the brainstem and filum terminale
TL;DR: A repair strategy based on transplantation of adult NPCs in neural repair after severe motor nerve injuries is suggested, and the filum terminale is a potential source of NPCs in future autologous cell therapies, even in human.
Dissertation
Human neural stem cells: region-specific properties and prospects for cell therapy
TL;DR: Cortical and striatal NSCs derived from the human fetus as a safe cell source with a very strong neurogenic capacity as promising candidates for cell replacement therapy are considered.
Astrocytes in development, aging and disease: starring GFAP
TL;DR: It is shown that different subtypes of astrocytes comprise specialized GFAP-IF networks, that change during development, aging and Alzheimer’s disease, and the novel functions that have emerged for the IF network suggest these changes can play an important part in the specialized function of these cells in both normal functions and brain disorders.
Book ChapterDOI
Using the QAPgrid Visualization Approach for Biomarker Identification of Cell-Specific Transcriptomic Signatures
TL;DR: This chapter illustrates the use of an integrated mathematical method for joint clustering and visualization of large-scale datasets and aims to identify differentially expressed genes according to cell type by building molecular signatures supported by statistical scores.
References
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Journal ArticleDOI
Neurogenesis in the adult human hippocampus
Peter S. Eriksson,Ekaterina Perfilieva,Thomas Björk-Eriksson,Ann Marie Alborn,Claes Nordborg,Daniel A. Peterson,Fred H. Gage +6 more
TL;DR: It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
Journal ArticleDOI
Neuronal replacement from endogenous precursors in the adult brain after stroke
TL;DR: It is shown that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone, and stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion.
Journal ArticleDOI
SOX2 Functions to Maintain Neural Progenitor Identity
TL;DR: It is shown here that constitutive expression of SOX2 inhibits neuronal differentiation and results in the maintenance of progenitor characteristics, and that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitors.
Journal ArticleDOI
From head to toes: The multiple facets of Sox proteins
TL;DR: Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context, and exhibit a remarkable crosstalk and functional redundancy among each other.
Journal ArticleDOI
Vertebrate neurogenesis is counteracted by Sox1–3 activity
TL;DR: It is reported that expression of the transcription factors Sox1, Sox2 and Sox3 (Sox1–3) is a critical determinant of neurogenesis and the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins.