Journal ArticleDOI
Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone.
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TLDR
Investigation of the distribution and characterization of Sox-2 and Pax-6 in the human subventricular zone (SVZ) reveals that these TFs are differentially expressed in the adult human SVZ where Sox- 2 and Pax -6 specify a glial and neuronal fate, respectively.About:
This article is published in Experimental Neurology.The article was published on 2007-04-01. It has received 41 citations till now. The article focuses on the topics: Subventricular zone & Neurogenesis.read more
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Dynamic expression of NR2F1 and SOX2 in developing and adult human cortex: comparison with cortical malformations
Benedetta Foglio,Laura Rossini,Rita Garbelli,Maria Cristina Regondi,Sara Mercurio,Michele Bertacchi,Laura Avagliano,Gaetano Bulfamante,Roland Coras,Antonino Maiorana,Silvia K. Nicolis,Michèle Studer,Carolina Frassoni +12 more
TL;DR: In this article, the expression dynamics of NR2F1 and SOX2, key cortical genes whose mutations in human patients cause severe neurodevelopmental syndromes, were explored.
The endogenous repair capacity of the parkinsonian brain
TL;DR: In this paper, van den Berge investigates stamcellen in volwassen menselijke hersenen of Parkinson patients, and finds that they are gezonde mensen van dezelfde leeftijd.
Human neural stem cell therapy in a primate model for Parkinson's disease
TL;DR: Evidence supports the standing argument that fetal subventricular-zone derived NSC do not significantly differentiate into mature A9-subtype midbrain dopamine neurons in-vivo, even in a GDNF-rich environment.
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Evaluation of human umbilical cord blood as a source of embryonic stem cells
TL;DR: HUCB is a rich source for MSCs with embryonic characteristics, and expresses the adipogenic FABP-4, osteogenic osteocalcin, chondrogenic aggrecan and neural Olig-4 and SOX2 markers after differentiation.
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Immunocytochemical characterisation of neural stem-progenitor cells from green terror cichlid Aequidens rivulatus.
TL;DR: It is confirmed that NSPCs obtained from A. rivulatus brains can proliferate and differentiate into neurons in vitro and clonal culture can be useful for further studying the distinct N SPCs.
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Neurogenesis in the adult human hippocampus
Peter S. Eriksson,Ekaterina Perfilieva,Thomas Björk-Eriksson,Ann Marie Alborn,Claes Nordborg,Daniel A. Peterson,Fred H. Gage +6 more
TL;DR: It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
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Neuronal replacement from endogenous precursors in the adult brain after stroke
TL;DR: It is shown that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone, and stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion.
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SOX2 Functions to Maintain Neural Progenitor Identity
TL;DR: It is shown here that constitutive expression of SOX2 inhibits neuronal differentiation and results in the maintenance of progenitor characteristics, and that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitors.
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From head to toes: The multiple facets of Sox proteins
TL;DR: Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context, and exhibit a remarkable crosstalk and functional redundancy among each other.
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Vertebrate neurogenesis is counteracted by Sox1–3 activity
TL;DR: It is reported that expression of the transcription factors Sox1, Sox2 and Sox3 (Sox1–3) is a critical determinant of neurogenesis and the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins.