Journal ArticleDOI
Specific release of plasma membrane enzymes by a phosphatidylinositol-specific phospholipase C.
M.G. Low,J.Bryan Finean +1 more
TLDR
It was concluded that release was not a secondary consequence of membrane vesiculation but occurred as a result of the disruption of specific interactions involving the phosphatidylinositol molecule.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1978-04-20. It has received 173 citations till now. The article focuses on the topics: Phospholipase C & Phosphatidylinositol.read more
Citations
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Journal ArticleDOI
Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes
Martin G. Low,Alan R. Saltiel +1 more
TL;DR: Glycosylated forms of phosphatidylinositol, which have only recently been described in eukaryotic organisms, are now known to play important roles in biological membrane function and may also be involved in signal transduction mechanisms for the hormone insulin.
Journal ArticleDOI
The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research
TL;DR: Apart from providing stable membrane anchorage, GPI anchors have been implicated in the sequestration of GPI-anchored proteins into specialised membrane microdomains, known as lipid rafts, and in signal transduction events.
Journal ArticleDOI
The glycosyl-phosphatidylinositol anchor of membrane proteins.
TL;DR: Etude de la synthese des groupements fonctionnels glycosyl-phosphatidylinositol se liant aux extremites C terminales des proteines procaryotique ou eucaryotiques, permettant leur determination et leur identification.
Journal ArticleDOI
Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system
TL;DR: The paper discusses the biochemical properties, cellular localization and functional properties of surface-located enzymes that hydrolyse nucleotides released from nervous tissue and indicates that 5'-nucleotidase appears to have a preferential glial allocation in the adult mammal.
Journal ArticleDOI
Glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein.
TL;DR: The COOH terminus of the externally disposed variant surface glycoprotein (VSG) of the eukaryotic pathogenic protozoan Trypanosoma brucei strain 427 variant MITat 1.4 (117) is covalently linked to a novel phosphatidylinositol-containing glycolipid.
References
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Journal ArticleDOI
The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases.
Journal ArticleDOI
The site of diphosphoinositide synthesis in rat liver.
Robert H. Michell,J.N. Hawthorne +1 more
Journal ArticleDOI
Plasma membranes of mammalian cells. A review of methods for their characterization and isolation
TL;DR: By isolating plasma membranes from the proper cell types, it should be possible to design experiments with more direct bearing on the functions of this organelle, and most studies on plasma membranes are concerned simply with their chemical and enzymatic compositions.
Journal ArticleDOI
Microdetermination of Inorganic Phosphate, Phospholipids, and Total Phosphate in Biologic Materials
TL;DR: A rapid, reproducible, and sensitive procedure for the determination of phosphate in several biologic materials is described and it is unnecessary to extract the heteropoly acid complex to increase sensitivity or to protect the color complex formed from interference of phosphate hydrolyzed during the process of color formation.
Related Papers (5)
A Glycophospholipid Tail at the Carboxyl Terminus of the Thy-1 Glycoprotein of Neurons and Thymocytes
Phosphatidylinositol is the membrane-anchoring domain of the Thy-1 glycoprotein
Martin G. Low,Paul W. Kincade +1 more