Journal ArticleDOI
Sperm DNA fragmentation negatively correlates with velocity and fertilization rates but might not affect pregnancy rates
Chun-Chia Huang,David Pei-Cheng Lin,Hui-Mei Tsao,Tzu-Chun Cheng,Chung-Hsien Liu,Maw-Sheng Lee +5 more
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The results indicated that sperm DNA fragmentation affects fertilization rates and sperm motility but might not affect pregnancy rates.About:
This article is published in Fertility and Sterility.The article was published on 2005-07-01. It has received 146 citations till now. The article focuses on the topics: Intracytoplasmic sperm injection & Sperm motility.read more
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Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis
Laura Kelly Thomson,Steven D. Fleming,Robert John Aitken,G. N. De Iuliis,Julie-Anne Zieschang,Anne Melton Clark +5 more
TL;DR: Human sperm DNA fragmentation is associated with an increase in oxidative stress during cryopreservation, rather than the activation of caspases and apoptosis, and the estrogenic compound genistein may be useful in reducing this effect.
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Do sperm DNA integrity tests predict pregnancy with in vitro fertilization
TL;DR: The small but statistically significant association between sperm DNA integrity test results and pregnancy in IVF and ICSI cycles is not strong enough to provide a clinical indication for routine use of these tests in infertility evaluation of men.
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Biological and clinical significance of DNA damage in the male germ line.
TL;DR: The type, source and measurement of DNA damage in human spermatozoa is considered, the clinical utility of the information generated in such studies is addressed, and areas where further research is needed to bridge the gap between an intriguing biological phenomenon and the evidence-based clinical management of male patients characterized by high levels of DNADamage.
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Are Tests of Sperm DNA Damage Clinically Useful? Pros and Cons
Armand Zini,Mark Sigman +1 more
TL;DR: In this article, the authors discuss the etiology of sperm DNA damage, describe individual tests of sperm damage, and explore the relationship between sperm DNA damages and pregnancy outcomes, and conclude that impaired sperm DNA integrity may have the greatest effect on IUI pregnancy rates and pregnancy loss by IVF and ICSI.
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The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta-analysis
TL;DR: High sperm DNA fragmentation in couples undergoing assisted reproduction techniques is associated with lower LBR, and well-designed randomized studies are required to assess the role of ICSI over IVF in the treatment of men with high spermDNA fragmentation.
References
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Human gene expression first occurs between the four- and eight-cell stages of preimplantation development
TL;DR: Changes in the pattern of polypeptides synthesized during the pre-implantation stages of human development are described, and it is demonstrated that some of the major qualitative changes which occur between the four- and eight-cell stages are dependent on transcription.
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Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro.
TL;DR: Since extremely poor semen samples are the indication for intracytoplasmic sperm injection, there is a high likelihood that sperm with fragmented DNA may be selected by chance and used for oocyte injection, resulting in poor fertilization and/or cleavage rates.
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DNA Integrity in Human Spermatozoa: Relationships With Semen Quality
TL;DR: It is concluded that a significant proportion of infertile men have elevated levels of DNA damage in their ejaculated spermatozoa.
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The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) and its relationship to fertilization and embryo development.
TL;DR: High loads of DNA damage measured by the Comet assay were predictive of failure of embryo development after ICSI, and it is likely that sperm with DNA damage contributed to successful fertilization and in-vitro development.
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Sperm Deoxyribonucleic Acid Fragmentation is Increased in Poor-Quality Semen Samples and Correlates with Failed Fertilization in Intracytoplasmic Sperm Injection 1
TL;DR: The results suggest that when poor-quality semen samples are used for ICSI, there is a greater likelihood that some sperm selected for injection, despite appearing normal, contain fragmented DNA.