Standardized Endpoint Definitions for Transcatheter Aortic Valve Implantation Clinical Trials
Martin B. Leon,Nicolo Piazza,Eugenia Nikolsky,Eugene H. Blackstone,Donald E. Cutlip,Arie Pieter Kappetein,Mitchell W. Krucoff,Michael Mack,Roxana Mehran,Craig Miller,Marie-Angèle Morel,John W. Petersen,Jeffrey J. Popma,Johanna J.M. Takkenberg,Alec Vahanian,Gerrit-Anne van Es,Pascal Vranckx,John G. Webb,Stephan Windecker,Patrick W. Serruys +19 more
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TLDR
Although consensus criteria will invariably include certain arbitrary features, an organized multidisciplinary process to develop specific definitions for TAVI clinical research should provide consistency across studies that can facilitate the evaluation of this new important catheter-based therapy.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2011-01-18 and is currently open access. It has received 868 citations till now. The article focuses on the topics: Clinical endpoint & Clinical trial.read more
Citations
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Third universal definition of myocardial infarction
Kristian Thygesen,Joseph S. Alpert,Allan S. Jaffe,Maarten L. Simoons,Bernard R. Chaitman,Harvey D. White +5 more
TL;DR: Information on MI rates can provide useful information regarding the burden of CAD within and across populations, especially if standardized data are collected in a manner that …
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
Ravindra L. Mehta,John A. Kellum,Sudhir V. Shah,Bruce A. Molitoris,Claudio Ronco,David G. Warnock,Adeera Levin +6 more
TL;DR: An initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI is described.
Journal ArticleDOI
Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
Craig R. Smith,Martin B. Leon,Michael J. Mack,D. Craig Miller,Jeffrey W. Moses,Lars G. Svensson,E. Murat Tuzcu,John G. Webb,Gregory P. Fontana,Raj Makkar,Mathew R. Williams,Todd M. Dewey,Samir R. Kapadia,Vasilis Babaliaros,Vinod H. Thourani,Paul J. Corso,Augusto D. Pichard,Joseph E. Bavaria,Howard C. Herrmann,Jodi J. Akin,William N. Anderson,Duolao Wang,Stuart J. Pocock +22 more
TL;DR: In high-risk patients with severe aortic stenosis, transcatheter and surgical procedures for aorti-valve replacement were associated with similar rates of survival at 1 year, although there were important differences in periprocedural risks.
Journal ArticleDOI
Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document.
A. Pieter Kappetein,Stuart J. Head,Philippe Généreux,Nicolo Piazza,Nicolas M. Van Mieghem,Eugene H. Blackstone,Thomas G. Brott,David J. Cohen,Donald E. Cutlip,Gerrit Anne van Es,Rebecca T. Hahn,Ajay J. Kirtane,Mitchell W. Krucoff,Susheel Kodali,Michael J. Mack,Roxana Mehran,Josep Rodés-Cabau,Pascal Vranckx,John G. Webb,Stephan Windecker,Patrick W. Serruys,Martin B. Leon +21 more
TL;DR: This VARC-2 document has provided further standardization of endpoint definitions for studies evaluating the use of TAVI, which will lead to improved comparability and interpretability of the study results, supplying an increasingly growing body of evidence with respect to TAVi and/or surgical aortic valve replacement.
Journal ArticleDOI
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Hugh Calkins,Karl-Heinz Kuck,Riccardo Cappato,Josep Brugada,A. John Camm,Shih Ann Chen,Harry J.G.M. Crijns,Ralph J. Damiano,D. Wyn Davies,John P. DiMarco,James R. Edgerton,Kenneth A. Ellenbogen,Michael D. Ezekowitz,David E. Haines,Michel Haïssaguerre,Gerhard Hindricks,Yoshito Iesaka,Warren M. Jackman,José Jalife,Pierre Jaïs,Jonathan M. Kalman,David Keane,Younghoon Kim,Paulus Kirchhof,Paulus Kirchhof,George J. Klein,Hans Kottkamp,Koichiro Kumagai,Bruce D. Lindsay,Moussa Mansour,Francis E. Marchlinski,Patrick M. McCarthy,J. Lluis Mont,Fred Morady,Koonlawee Nademanee,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Douglas L. Packer,Carlo Pappone,Eric N. Prystowsky,Antonio Raviele,Vivek Y. Reddy,Jeremy N. Ruskin,Richard J. Shemin,Hsuan Ming Tsao,David J. Wilber,Niv Ad,Jennifer E. Cummings,A. Mark Gillinov,Hein Heidbuchel,Craig T. January,Gregory Y.H. Lip,Steven M. Markowitz,Mohan Nair,I. Eli Ovsyshcher,Hui Nam Pak,Takeshi Tsuchiya,Dipen Shah,Teo Wee Siong,Panos E. Vardas +60 more
TL;DR: This 2012 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a Task Force, convened by the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society and charged with defining the indications, techniques, and outcomes of this procedure.
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Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
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