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stem cells Long-term repopulating ability of telomerase-deficient murine hematopoietic
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The article was published on 2013-01-01 and is currently open access. It has received 1 citations till now. The article focuses on the topics: Stem cell & Adult stem cell.read more
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Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
Shu-Chun Teng,Virginia A. Zakian +1 more
TL;DR: The very long and heterogeneous-length telomeres characteristic of type II survivors in Saccharomyces are reminiscent of the telomere in immortal human cell lines and tumors that maintain telomeric DNA in the absence of telomerase.
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Journal ArticleDOI
Specific association of human telomerase activity with immortal cells and cancer
Nam Woo Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay +9 more
TL;DR: A highly sensitive assay for measuring telomerase activity was developed in this paper, which showed that telomerases appear to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
Journal ArticleDOI
Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.
Journal ArticleDOI
Structure and function of telomeres
TL;DR: The DNA of telomeres—the terminal DNA-protein complexes of chromosomes—differs notably from other DNA sequences in both structure and function, and has been shown to be essential for telomere maintenance and long-term viability.
Journal ArticleDOI
Telomere length predicts replicative capacity of human fibroblasts.
Richard C. Allsopp,Homayoun Vaziri,Christopher Patterson,S Goldstein,Edward V. Younglai,A B Futcher,Carol W. Greider,Calvin B. Harley +7 more
TL;DR: Telomere length is a biomarker of somatic cell aging in humans and is consistent with a causal role for telomere loss in this process, and fibroblasts from Hutchinson-Gilford progeria donors had short telomeres, consistent with their reduced division potential in vitro.
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Maria A. Blasco,Maria A. Blasco,Han Woong Lee,M. Prakash Hande,Enrique Samper,Peter M. Lansdorp,Ronald A. DePinho,Carol W. Greider,Carol W. Greider +8 more
TL;DR: Results indicate that telomerase is essential for telomere length maintenance but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice.