Journal ArticleDOI
Steroid biosynthesis by zona fasciculata and zona reticularis cells purified from the mammalian adrenal cortex.
P.J. Hyatt,K. Bhatt,J.F. Tait +2 more
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TLDR
The preliminary experiment on human adrenal cells indicates that the ZR cells are much more important than the ZF cells in the production of androgens even in the presence of ACTH, in contrast to the other species studied.About:
This article is published in Journal of Steroid Biochemistry.The article was published on 1983-07-01. It has received 34 citations till now. The article focuses on the topics: Zona reticularis & Adrenal cortex.read more
Citations
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Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
Anita H. Payne,Dale B. Hales +1 more
TL;DR: This review presents a detailed description of the enzymes involved in the biosynthesis of active steroid hormones, with emphasis on the human and mouse enzymes and their expression in gonads, adrenal glands, and placenta.
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Premature adrenarche--normal variant or forerunner of adult disease?
TL;DR: The well documented evolution of adrenarche in primates and man is incompatible with either a neutral or harmful role for DHEA and implies most likely a positive role for some aspect of young adult pubertal maturation and developmental maturation.
Journal ArticleDOI
Resistance exercise overtraining and overreaching. Neuroendocrine responses
Andrew C. Fry,William J. Kraemer +1 more
TL;DR: Overtraining is defined as an increase in training volume and/or intensity of exercise resulting in performance decrements, and some of the neuroendocrine characteristics often suggested as markers of overtraining may not be applicable to some overtraining scenarios.
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Insulin and hyperandrogenism in women with polycystic ovary syndrome.
TL;DR: New concepts and findings regarding insulin actions in PCOS women and how it is related to hyperandrogenemia are discussed.
Journal ArticleDOI
The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta-hydroxysteroid dehydrogenase
TL;DR: The most likely cause of the age-related decline in adrenal androgen biosynthesis is an age- related decline in the number of functional reticularis cells, without a major change in the differentiated properties of the zonal cells as a function of age.
References
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Adrenarche: A Survey of Rodents, Domestic Animals, and Primates
Gordon B. Cutler,Michael Glenn,R. Mitchell Bush,Gary D. Hodgen,Charles E. Graham,D. Lynn Loriaux +5 more
TL;DR: It is apparent that adrenal androgen levels and their developmental patterns differ markedly among species, and that among the species examined, only the chimpanzee exhibits an adrenarche comparable to that of man.
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The Prepuberal and Puberal Growth of the Adrenal (Adrenarche)
TL;DR: The increase in adrenal weight and structural development of the cortex is studied in 630 pairs of adrenals from children between 1 and 19 years and in 22 cases a delayed adrenarche is found, bringing into relation with production of androgens.
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Adrenarche: Changing Adrenal Response to Adrenocorticotropin
TL;DR: Overnight dexamethasone suppression led to reduction of most steroids in most groups, and the hypothesis that adrenarche results from an altered biosynthetic response to ACTH was tested.
Journal Article
Observations on the fine structure of the adrenal cortex of man.
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A biochemical investigation of the functional zonation of the adrenal cortex in man.
TL;DR: The zones of human adrenal cortices have been separated by slicing and their chemical composition and steroid biosynthetic activity in vitro examined and theories of the functional zonation of the adrenal cortex in man are discussed.