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Stress hormones: Their interaction and regulation.
Julius Axelrod,Terry Reisine +1 more
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TLDR
Together these agents appear to determine the complex physiologic responses to a variety of stressors.Abstract:
Stress stimulates several adaptive hormonal responses. Prominent among these responses are the secretion of catecholamines from the adrenal medulla, corticosteroids from the adrenal cortex, and adrenocorticotropin from the anterior pituitary. A number of complex interactions are involved in the regulation of these hormones. Glucocorticoids regulate catecholamine biosynthesis in the adrenal medulla and catecholamines stimulate adrenocorticotropin release from the anterior pituitary. In addition, other hormones, including corticotropin-releasing factor, vasoactive intestinal peptide, and arginine vasopressin stimulate while the corticosteroids and somatostatin inhibit adrenocorticotropin secretion. Together these agents appear to determine the complex physiologic responses to a variety of stressors.read more
Citations
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Interleukin 1 potentiates the secretion of beta-endorphin induced by secretagogues in a mouse pituitary cell line (AtT-20)
TL;DR: IL-1 enhances peptide-generated secretion of beta-endorphin by inducing protein kinase C, which suggests that IL-1 does not induce adenylate cyclase and that forskolin causes the secretion ofbeta-endomorphin by a mechanism independent of cAMP.
Journal ArticleDOI
Cross-talk between adrenal medulla and adrenal cortex in stress
TL;DR: The data summarized here indicate an involvement of intra‐adrenal interactions in this coordination of the body's response to stress.
Journal ArticleDOI
Sensitization of sympathetic-adrenal medullary responses to a novel stressor in chronically stressed laboratory rats.
TL;DR: Three experiments in which laboratory rats were exposed daily for 26 consecutive days to the same (homotypic) stressor and then challenged with a novel (heterotypic), providing evidence for a sensitization of sympathetic-adrenal medullary responses to a novel stressor in animals previously exposed to chronic intermittent stress.
Journal ArticleDOI
The immune system and integrated homeostasis.
TL;DR: Evidence that communication pathways exist between the immune and central nervous systems which support bi‐directional information flow, and that the output of the immune system influences other physiological adjustments to environmental change, is discussed.
Journal ArticleDOI
Modulation of cytokine production by dehydroepiandrosterone (DHEA) plus melatonin (MLT) supplementation of old mice.
Paula Inserra,Zhen Zhang,Sussan K. Ardestani,Mohsen Araghi-Niknam,Bailin Liang,Shuguang Jiang,Don Shaw,Mark Molitor,Kerry K. Elliott,Ronald R. Watson +9 more
TL;DR: DHEA and MLT effectively modulate suppressed Th1 cytokine and elevated Th2 cytokine production; however, their combined use produced only a limited additive effect.
References
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Journal ArticleDOI
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
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A Syndrome produced by Diverse Nocuous Agents
TL;DR: If the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed.
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Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.
TL;DR: Modification of the original single isotope radioenzymatic assay of Passon and Peuler permits the direct and simultaneous analysis of norepinephrine, epinephrine and dopamine in plasma samples of 50 μl or less.