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Stress hormones: Their interaction and regulation.
Julius Axelrod,Terry Reisine +1 more
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Together these agents appear to determine the complex physiologic responses to a variety of stressors.Abstract:
Stress stimulates several adaptive hormonal responses. Prominent among these responses are the secretion of catecholamines from the adrenal medulla, corticosteroids from the adrenal cortex, and adrenocorticotropin from the anterior pituitary. A number of complex interactions are involved in the regulation of these hormones. Glucocorticoids regulate catecholamine biosynthesis in the adrenal medulla and catecholamines stimulate adrenocorticotropin release from the anterior pituitary. In addition, other hormones, including corticotropin-releasing factor, vasoactive intestinal peptide, and arginine vasopressin stimulate while the corticosteroids and somatostatin inhibit adrenocorticotropin secretion. Together these agents appear to determine the complex physiologic responses to a variety of stressors.read more
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Prospective controlled studies of the behavioral and biological effects of exogenous corticosteroids
TL;DR: The preliminary data raise the possibility that the behavioral effects of exogenous corticosteroids have specific neural concomitants and that the pattern of biological changes produced contributes to the behavioral variability observed.
Journal ArticleDOI
CRF receptor regulation and sensitization of ACTH responses to acute ether stress during chronic intermittent immobilization stress.
TL;DR: CRF receptors in the olfactory bulb were unchanged following acute or chronic restraint stress, consistent with previous observations that brain CRF receptors are neither changed by adrenalectomy, glucocorticoid administration, nor 18-48 h of continuous restraint stress.
Journal ArticleDOI
Stress-related activation of cerebral dopaminergic systems.
TL;DR: It is found that the DA response in stress is global like that of norepinephrine, and not specific to the prefrontal cortex, and intracerebroventricular injection of corticotropin-releasing factor produces stresslike increases in DOPAC and MHPG concentrations.
Journal ArticleDOI
Chronic work stress, sickness absence, and hypertension in middle managers: general or specific sociological explanations?
Richard Peter,Johannes Siegrist +1 more
TL;DR: A sociological model of work stress which allows for differential prediction of health outcomes according to the important notions of active versus passive coping with work demands finds preliminary empirical support.
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Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats.
TL;DR: The results suggest that endogenous glucocorticoids restrain responses of catecholamine turnover, synthesis, release, reuptake, and metabolism in sympathetic nerves in this stress model.
References
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Journal ArticleDOI
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
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A Syndrome produced by Diverse Nocuous Agents
TL;DR: If the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed.
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Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.
TL;DR: Modification of the original single isotope radioenzymatic assay of Passon and Peuler permits the direct and simultaneous analysis of norepinephrine, epinephrine and dopamine in plasma samples of 50 μl or less.