Open Access
Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes
TLDR
This mini-review focuses exclusively on structural and functional features of mammalian alkaline phosphatases as identified by crystallography and probed by site-directed mutagenesis and kinetic analysis.Citations
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Aggregation-Induced Emission: Together We Shine, United We Soar!
TL;DR: This paper presents a meta-analysis of the chiral stationary phase transition of Na6(CO3)(SO4)2, a major component of the response of the immune system to Na2CO3.
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Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade.
TL;DR: Recent advances in nucleotide-releasing and purine-converting pathways in the vasculature are summarized, with particular emphasis on the nucleotidases of ecto-nucleoside triphosphate diphosphatase/phosphodiesterase family.
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Cellular function and molecular structure of ecto-nucleotidases
TL;DR: The review focuses on the principal biochemical, cell biological, catalytic, and structural properties of the enzymes and provides brief reference to tissue distribution, and physiological and pathophysiological functions.
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Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet
TL;DR: IAP has a pivotal role in intestinal homeostasis and its activity could be increased through the diet, especially true in pathological situations in which the involvement of commensal bacteria is suspected and when intestinal AP is too low to detoxify a sufficient amount of bacterial lipopolysaccharide.
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Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities.
TL;DR: This review describes recent advances in this field, with special emphasis on purine-converting ectoenzymes as a complex and integrated network regulating purinergic signaling in such (patho)physiological states as immunomodulation, inflammation, tumorigenesis, arterial calcification and other diseases.
References
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Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
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Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes
Martin G. Low,Alan R. Saltiel +1 more
TL;DR: Glycosylated forms of phosphatidylinositol, which have only recently been described in eukaryotic organisms, are now known to play important roles in biological membrane function and may also be involved in signal transduction mechanisms for the hormone insulin.
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Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
Lovisa Hessle,Kristen Johnson,H. Clarke Anderson,Sonoko Narisawa,Adnan Sali,James W. Goding,Robert Terkeltaub,José Luis Millán +7 more
TL;DR: The results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia, and interfere with TNAP activity may correct pathological hyperossification because of PPi insufficiency.
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Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization.
TL;DR: How ALP acts was clarified by the discoveries that several phosphocompound substrates for tissue-nonspecific ALP (TNSALP) accumulate endogenously in this inborn error of metabolism.
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Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
Dympna Harmey,Lovisa Hessle,Sonoko Narisawa,Kristen Johnson,Robert Terkeltaub,José Luis Millán +5 more
TL;DR: In this article, the authors crossbred Akp2−/− mice to ank/ank mice and found a partial normalization of the mineralization phenotypes and PPi levels.