Journal ArticleDOI
Studies on antianaphylactic agents—III
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TLDR
By the application of the Vilsmeier-Haack reaction to various o-hydroxyacetophenone derivatives, 4-oxo-4H-1-benzopyran-3-carboxaldehydes were synthesized in one step as discussed by the authors.About:
This article is published in Tetrahedron.The article was published on 1974-01-01. It has received 175 citations till now. The article focuses on the topics: Fragmentation (mass spectrometry) & Mass spectrum.read more
Citations
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Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines
Hoang Le Tuan Anh,Nguyen Thi Cuc,Bui Huu Tai,Pham Hai Yen,Nguyen Xuan Nhiem,Do Thi Thao,Nguyen Hoai Nam,Chau Van Minh,Phan Van Kiem,Young Ho Kim +9 more
TL;DR: Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol and showed the most selective cytotoxic effects against human epidermoid carcinoma and breast cancer cell lines, suggesting that chromoylth Diazolidines are potential low-cost, and selective anticancer agents.
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Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK epsilon for the treatment of obesity.
Tyler S. Beyett,Xinmin Gan,Shannon M. Reilly,Andrew V. Gomez,Louise Chang,John J.G. Tesmer,Alan R. Saltiel,H. D. Hollis Showalter +7 more
TL;DR: A series of analogues was synthesized to develop a structure activity relationship (SAR) around the A- and C-rings of the core scaffold toward uncovering analogues with development potential and provide impetus to expand the SAR around the amlexanox core.
Journal ArticleDOI
Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.
TL;DR: Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-amino-3- formyl chromones with bCA inhibitory activity determined.
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Synthesis of 4H-Chromen-4-one Derivatives by Intramolecular Palladium-Catalyzed Acylation of Alkenyl Bromides with Aldehydes.
TL;DR: The palladium-catalyzed intramolecular acylation of alkenyl bromides and aldehydes was developed for an efficient synthesis of 4H-chromen-4-ones and applied to synthesize a small library of diversely functionalized flavonoids in moderate to good yields in 1,4-dioxane.
Journal ArticleDOI
Uncatalyzed addition of indoles and N-methylpyrrole to 3-formylchromones: synthesis and some reactions of (chromon-3-yl)bis(indol-3-yl)methanes and E-2-hydroxy-3-(1-methylpyrrol-2-ylmethylene)chroman-4-ones
TL;DR: In this article, the reaction of (chromon-3-yl)bis(indol-3yl)methanes with guanidine carbonate and hydrazine hydrate proceed with the participation of the chromone ring system and lead to the formation of corresponding pyrimidines and pyrazoles bearing the bis-(indol-)methyl moiety.
References
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3‐Acylchromone. XV. Mitt. über Untersuchungen an γ‐Pyronen
Fritz Eiden,H. Haverland +1 more
TL;DR: In 2-Stellung unsubstituierte 3-Acyl-chromone wurden aus 2-Hydroxy-ω-acyl-acetophenonen durch Reaktion with Orthoameisensaure-triathylester und Acetanhydrid oder aus 1-hydroxy-α-formylacetophenon and Acetanehydrid/Natriumacetat dargestellt as mentioned in this paper.
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Synthetic analogs of cortical hormones. i. homogentisic acid and ,2,5-trihydroxyacetophenone derivatives from 2,5-diacetoxy--diazoacetophenone
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The reactions of 2,2‐difluoro‐4‐methylnaphtho[l,2‐e]‐1,3,2‐dioxaborin and its [2,1‐e]isomer with N,N‐dimethylformamide
TL;DR: In this paper, the title compounds react with dimethylformamide in acetic anhydride to give dimethylamino-vinyl derivatives which, on treatment with base, yield benzochroman-4-ones.
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Pharmacological actions of baicalin and baicalein
TL;DR: In this paper, Baicalin and Baicalein, components of the drug, were investigated on active anaphylactic reaction in guinea pig, and the results obtained were compared with those of rutin, methylhesperidin and quercetin.