Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease
John E. Wagner,Joseph Rosenthal,Joseph Rosenthal,Robert Sweetman,Robert Sweetman,Xiao-Ou Shu,Xiao-Ou Shu,Stella M. Davies,Stella M. Davies,Norma K.C. Ramsay,Norma K.C. Ramsay,Philip B. McGlave,Philip B. McGlave,Leonard S. Sender,Leonard S. Sender,Mitchell S. Cairo,Mitchell S. Cairo +16 more
TLDR
Cryopreserved umbilical cord blood from HLA-matched and mismatched unrelated donors is a sufficient source of transplantable hematopoietic stem cells with high probability of donor derived engraftment and low risk of refractory severe acute graft-versus-host disease.About:
This article is published in Blood.The article was published on 1996-08-01 and is currently open access. It has received 643 citations till now. The article focuses on the topics: Umbilical Cord Blood Transplantation & Hematopoietic stem cell transplantation.read more
Citations
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Journal ArticleDOI
Outcomes among 562 Recipients of Placental-Blood Transplants from Unrelated Donors
Pablo Rubinstein,Carmelita Carrier,Andromachi Scaradavou,Joanne Kurtzberg,John W. Adamson,Anna Rita Migliaccio,Richard L. Berkowitz,Michael F. Cabbad,Dobrila Nl,Patricia E. Taylor,Richard E. Rosenfield,Cladd E. Stevens +11 more
TL;DR: Placental blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution and is associated with the severity of GVHD, type of leukemia, and stage of the disease.
Journal ArticleDOI
Outcome of cord-blood transplantation from related and unrelated donors
Eliane Gluckman,Vanderson Rocha,Agnes Boyer-Chammard,Franco Locatelli,William Arcese,Ricardo Pasquini,Juan Ortega,Gerard Souillet,Euripedes Ferreira,Jean Philippe Laporte,M.N. Fernández,Claude Chastang +11 more
TL;DR: A registry containing information on the outcome of cord-blood transplantation from 1988 to 1996 was established, and younger age, lower weight, transplants from HLA-identical donors, and cytomegalovirus-negative serologic results in the recipient were favorable prognostic factors.
Journal ArticleDOI
Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival.
John E. Wagner,Juliet N. Barker,Todd E. DeFor,K. Scott Baker,Bruce R. Blazar,Cindy R. Eide,Anne I. Goldman,John H. Kersey,William Krivit,Margaret L. MacMillan,Paul J. Orchard,Charles Peters,Daniel J. Weisdorf,Norma K.C. Ramsay,Stella M. Davies +14 more
TL;DR: There is a high probability of survival in recipients of UCB grafts that are disparate in no more than 2 human leukocyte antigens when the grafts contain at least 1.7 x 10(5) CD34(+) cells per kilogram of recipient's body weight, and graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less.
Journal ArticleDOI
Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia
Mary J. Laughlin,Mary Eapen,Pablo Rubinstein,John E. Wagner,Mei Jei Zhang,Richard E. Champlin,Cladd E. Stevens,Juliet N. Barker,Robert Peter Gale,Hillard M. Lazarus,David I. Marks,Jon J. van Rood,Andromachi Scaradavou,Mary M. Horowitz +13 more
TL;DR: HLA-mismatched cord blood should be considered an acceptable source of hematopoietic stem-cell grafts for adults in the absence of an HLA-matched adult donor.
Journal ArticleDOI
Hematopoietic Engraftment and Survival in Adult Recipients of Umbilical-Cord Blood from Unrelated Donors
Mary J. Laughlin,Juliet N. Barker,Barbara Bambach,Omer N. Koc,David A. Rizzieri,John E. Wagner,Stanton L. Gerson,Hillard M. Lazarus,Mitchell S. Cairo,Cladd E. Stevens,Pablo Rubinstein,Joanne Kurtzberg +11 more
TL;DR: Umbilical-cord blood from unrelated donors can restore hematopoiesis in adults who receive myeloablative therapy and is associated with acceptable rates of severe acute and chronic GVHD.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors.
Glucksberg H,Rainer Storb,Alexander Fefer,C. D. Buckner,Paul E. Neiman,Clift Ra,Lerner Kg,Thomas Ed +7 more
TL;DR: The results show that despite histocompatibility matching and methotrexate therapy, GVHD remains a serious and often fatal complication of marrow transplantation.
Journal ArticleDOI
Hematopoietic reconstitution in a patient with fanconi's anemia by means of umbilical-cord blood from an hla-identical sibling
Eliane Gluckman,Hal E. Broxmeyer,Arleen D. Auerbach,Henry S. Friedman,Gordon W. Douglas,Agnès Devergie,Helene Esperou,Dominique Thierry,Gérard Socié,Pierre Lehn,Scott Cooper,Denis English,Joanne Kurtzberg,Judith Bard,Edward A. Boyse +14 more
TL;DR: It is necessary to select patients suitable for vaginal or laparoscopic mesh placement for Fanconi's anemia preoperatively on the basis of prior history and once they provide informed consent for surgery.
Journal ArticleDOI
Analysis of 462 transplantations from unrelated donors facilitated by the national marrow donor program
Nancy A. Kernan,Glenn E. Bartsch,Robert C. Ash,Patrick G. Beatty,Richard E. Champlin,Alexandra H. Filipovich,James Gajewski,John A. Hansen,Jean P. Henslee-Downey,Jeffrey McCullough,Philip B. McGlave,Herbert A. Perkins,Gordon L. Phillips,Jean E. Sanders,David F. Stroncek,E. Donnall Thomas,Karl G. Blume +16 more
TL;DR: The National Marrow Donor Program has benefited a substantial number of patients in need of marrow transplants from closely HLA-matched unrelated donors and has facilitated the recruitment of unrelated donors into the donor pool and the access to suitable marrow.
Journal ArticleDOI
Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome.
Sergio Stagno,Robert F. Pass,Gretchen A. Cloud,William J. Britt,Ronald E. Henderson,Philip D. Walton,Dean A. Veren,Frank Page,Charles A. Alford +8 more
TL;DR: Primary CMV infection during pregnancy poses a 30% to 40% risk of intrauterine transmission and adverse outcome is more likely when infection occurs within the first half of gestation.