Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival.
John E. Wagner,Juliet N. Barker,Todd E. DeFor,K. Scott Baker,Bruce R. Blazar,Cindy R. Eide,Anne I. Goldman,John H. Kersey,William Krivit,Margaret L. MacMillan,Paul J. Orchard,Charles Peters,Daniel J. Weisdorf,Norma K.C. Ramsay,Stella M. Davies +14 more
TLDR
There is a high probability of survival in recipients of UCB grafts that are disparate in no more than 2 human leukocyte antigens when the grafts contain at least 1.7 x 10(5) CD34(+) cells per kilogram of recipient's body weight, and graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less.Citations
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Hematopoietic Stem-Cell Transplantation
TL;DR: Hematopoietic stem-cell transplantation was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically as mentioned in this paper.
Journal ArticleDOI
Graft-versus-host disease
TL;DR: The understanding of the risk factors and causes of GHVD, the cellular and cytokine networks implicated in its pathophysiology, and current strategies to prevent and treat the disease are reviewed.
Journal ArticleDOI
Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective.
Marcie Tomblyn,Tom Chiller,Hermann Einsele,Ronald E. Gress,Kent A. Sepkowitz,Jan Storek,John R. Wingard,Jo Anne H. Young,Michael Boeckh +8 more
TL;DR: Changes include the recommendations for PCV rather than PPSV-23 for pneumococcal vaccination, starting some vaccinations earlier post-transplant, and the addition of recommendations for Varivax, HPV vaccine, and (the non-use of) Zostavax vaccine are included.
Journal ArticleDOI
Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia
Vanderson Rocha,Myriam Labopin,Guillermo Sanz,William Arcese,Rainer Schwerdtfeger,Alberto Bosi,Niels Jacobsen,Tapani Ruutu,Marcos de Lima,Jürgen Finke,Francesco Frassoni,Eliane Gluckman +11 more
TL;DR: Cord blood from an unrelated donor is an alternative source of hematopoietic stem cells for adults with acute leukemia who lack an HLA-matched bone marrow donor.
Journal ArticleDOI
Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells
Anthony E. Boitano,Jian Wang,Russell Romeo,Laure C. Bouchez,Albert E. Parker,Sue E. Sutton,John R. Walker,Colin A. Flaveny,Gary H. Perdew,Michael S. Denison,Peter G. Schultz,Michael P. Cooke +11 more
TL;DR: Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR) and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors.
Glucksberg H,Rainer Storb,Alexander Fefer,C. D. Buckner,Paul E. Neiman,Clift Ra,Lerner Kg,Thomas Ed +7 more
TL;DR: The results show that despite histocompatibility matching and methotrexate therapy, GVHD remains a serious and often fatal complication of marrow transplantation.
Journal ArticleDOI
Outcomes among 562 Recipients of Placental-Blood Transplants from Unrelated Donors
Pablo Rubinstein,Carmelita Carrier,Andromachi Scaradavou,Joanne Kurtzberg,John W. Adamson,Anna Rita Migliaccio,Richard L. Berkowitz,Michael F. Cabbad,Dobrila Nl,Patricia E. Taylor,Richard E. Rosenfield,Cladd E. Stevens +11 more
TL;DR: Placental blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution and is associated with the severity of GVHD, type of leukemia, and stage of the disease.
Journal ArticleDOI
Outcome of cord-blood transplantation from related and unrelated donors
Eliane Gluckman,Vanderson Rocha,Agnes Boyer-Chammard,Franco Locatelli,William Arcese,Ricardo Pasquini,Juan Ortega,Gerard Souillet,Euripedes Ferreira,Jean Philippe Laporte,M.N. Fernández,Claude Chastang +11 more
TL;DR: A registry containing information on the outcome of cord-blood transplantation from 1988 to 1996 was established, and younger age, lower weight, transplants from HLA-identical donors, and cytomegalovirus-negative serologic results in the recipient were favorable prognostic factors.