Survivin and IAP proteins in cell-death mechanisms
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TLDR
The function of cell-death modifiers have considerably broadened over the last few years, and these molecules are increasingly recognized as arbiters of cellular homoeostasis, from cell division, to intracellular signalling to cellular adaptation.Abstract:
From the realization that cell number homoeostasis is fundamental to the biology of all metazoans, and that deregulation of this process leads to human diseases, enormous interest has been devoted over the last two decades to map the requirements of cell death and cell survival. This effort has led to tangible progress, and we can now chart with reasonable accuracy complex signalling circuitries controlling cell-fate decisions. Some of this knowledge has translated into novel therapeutics, and the outcome of these strategies, especially in cancer, is eagerly awaited. However, the function of cell-death modifiers have considerably broadened over the last few years, and these molecules are increasingly recognized as arbiters of cellular homoeostasis, from cell division, to intracellular signalling to cellular adaptation. This panoply of functions is best exemplified by members of the IAP (inhibitor of apoptosis) gene family, molecules originally narrowly defined as endogenous caspase inhibitors, but now firmly positioned at the crossroads of multiple normal and transformed cellular responses.read more
Citations
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DNA damage and the balance between survival and death in cancer biology
TL;DR: This Review described key decision-making nodes in the complex interplay between cell survival and death following DNA damage, which determine the outcome of cancer therapy with genotoxic drugs.
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DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis
Wynand P. Roos,Bernd Kaina +1 more
TL;DR: The main DNA damage recognition factors MRN and the PI3 kinases ATM, ATR and DNA-PK, which phosphorylate a multitude of proteins and thus induce the DNA damage response (DDR), will be discussed as well as the downstream players p53, NF-κB, Akt and survivin.
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Autophagy and apoptosis: where do they meet?
Subhadip Mukhopadhyay,Prashanta Kumar Panda,Niharika Sinha,Durgesh Nandini Das,Sujit K. Bhutia +4 more
TL;DR: The crucial factors governing the crosstalk between autophagy and apoptosis are highlighted and the mechanisms controlling cell survival and cell death are described.
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Apoptosis and oxidative stress in neurodegenerative diseases.
TL;DR: An overview of the involvement of neuronal apoptosis and oxidative stress in the most important neurodegenerative diseases is presented, mainly focusing the attention on several genetic disorders, discussing the interaction between primary genetic abnormalities and the apoptotic pathways.
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Apoptotic cell signaling in cancer progression and therapy.
TL;DR: The role of the BCL-2 family proteins, inhibitor of apoptosis (IAP) proteins, and FLICE-inhibitory protein in the context of normal apoptotic signaling mechanisms and dysregulated apoptotic pathways that can render cancer cells resistant to cell death are highlighted.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
The biochemistry of apoptosis
TL;DR: The basic components of the death machinery are reviewed, how they interact to regulate apoptosis in a coordinated manner is described, and the main pathways that are used to activate cell death are discussed.
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Cell Death: Critical Control Points
TL;DR: The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.