Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms
TLDR
Findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance are discussed are discussed.About:
This article is published in Cell Host & Microbe.The article was published on 2019-07-10 and is currently open access. It has received 300 citations till now. The article focuses on the topics: Multidrug tolerance & Biofilm.read more
Citations
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Antimicrobial resistance in ESKAPE pathogens
David M. P. De Oliveira,Brian M. Forde,Timothy J. Kidd,Patrick N A Harris,Mark A. Schembri,Scott A. Beatson,David L. Paterson,Mark J. Walker +7 more
TL;DR: The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antim antibiotic resistance surveillance.
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Advances in Antimicrobial Microneedle Patches for Combating Infections.
Rezvan Jamaledin,Cynthia K.Y. Yiu,Ehsan Nazarzadeh Zare,Li Na Niu,Raffaele Vecchione,Guojun Chen,Zhen Gu,Franklin R. Tay,Pooyan Makvandi,Pooyan Makvandi,Pooyan Makvandi +10 more
TL;DR: In the present review, skin anatomy and its barriers along with skin infection are discussed, and potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined.
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Biofilm exacerbates antibiotic resistance: Is this a current oversight in antimicrobial stewardship?
TL;DR: Although biofilm falls outside of the current definition of antimicrobial stewardship, greater awareness of the existence, ubiquity, and consequences of environmental biofilm amongst healthcare practitioners is crucial to improving hygiene practices and controlling the emergence of antibiotic resistance in healthcare facilities.
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Bioinspired oral delivery of gut microbiota by self-coating with biofilms.
TL;DR: A bioinspired strategy of self-coating with biofilms that endows the transplanted gut microbiota with superior resistance and adhesion capacity is described and suggests a robust platform for oral doses of gut microbiota.
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Quorum sensing for population-level control of bacteria and potential therapeutic applications
TL;DR: This review provides an update on QS applications based on autoinducer molecules including acyl-homoserine lactones, auto-inducing peptides, AI-2 and indole in population-level control of bacteria, and highlights the potential in developing novel clinical therapies.
References
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Bacterial biofilms: from the natural environment to infectious diseases.
TL;DR: It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments.
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Bacterial Persistence as a Phenotypic Switch
Nathalie Q. Balaban,Nathalie Q. Balaban,Jack Merrin,Remy Chait,Lukasz Kowalik,Stanislas Leibler +5 more
TL;DR: Investigating the persistence of single cells of Escherichia coli with the use of microfluidic devices found phenotypic switching occurred between normally growing cells and persister cells having reduced growth rates, leading to a simple mathematical description of the persistence switch.
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Staphylococcus epidermidis — the 'accidental' pathogen
TL;DR: The molecular basis of the commensal and infectious lifestyles of S. epidermidis is discussed, beginning to comprehend the roles in balancing the epithelial microflora and serving as a reservoir of resistance genes.
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Treatment of staphylococcal infections with penicillin by intermittent sterilisation
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Distinguishing between resistance, tolerance and persistence to antibiotic treatment.
TL;DR: This Opinion article describes recent studies of tolerance, resistance and persistence, outlining how a clear and distinct definition for each phenotype can be developed from these findings and proposes a framework for classifying the drug response of bacterial strains according to these definitions that is based on the measurement of the minimum inhibitory concentration.