Journal ArticleDOI
Sustained delivery of vascular endothelial growth factor with alginate beads.
TLDR
The results suggest that the alginate-VEGF delivery system may be useful in the development of vascular tissue engineering and wound healing applications.About:
This article is published in Journal of Controlled Release.The article was published on 2004-05-18. It has received 243 citations till now. The article focuses on the topics: Calcium alginate & Vascular endothelial growth factor.read more
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Journal ArticleDOI
Alginate: properties and biomedical applications
Kuen Yong Lee,David J. Mooney +1 more
TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
Journal ArticleDOI
Wound healing dressings and drug delivery systems: a review.
TL;DR: The requirement for formulations with improved properties for effective and accurate delivery of the required therapeutic agents and general formulation approaches towards achieving optimum physical properties and controlled delivery characteristics for an active wound healing dosage form are considered.
Journal ArticleDOI
Alginate composites for bone tissue engineering: a review.
TL;DR: Alginate based composite biomaterials will be promising for bone tissue regeneration because of their enhanced biochemical significance in terms of porosity, mechanical strength, cell adhesion, biocompatibility, cell proliferation, alkaline phosphatase increase, excellent mineralization and osteogenic differentiation.
Journal ArticleDOI
Naturally derived materials-based cell and drug delivery systems in skin regeneration.
Sha Huang,Xiaobing Fu +1 more
TL;DR: The contribution of natural materials and natural materials-based protein delivery systems to regenerative medicine research is illustrated, with emphasis on the application of multifunctional vehicles for cell and growth factor delivery in skin regeneration research.
Journal ArticleDOI
Injectable Stem Cell-Laden Photocrosslinkable Microspheres Fabricated Using Microfluidics for Rapid Generation of Osteogenic Tissue Constructs
Xin Zhao,Xin Zhao,Shen Liu,Lara Yildirimer,Hong Zhao,Ruihua Ding,Huanan Wang,Wenguo Cui,Wenguo Cui,David A. Weitz +9 more
TL;DR: It is found that BMSCs encapsulated in GelMA microspheres show enhanced osteogenesis in vitro and in vivo, associated with a significant increase in mineralization.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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The biology of VEGF and its receptors.
TL;DR: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and is implicated in pathologicalAngiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
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Angiogenesis in health and disease.
TL;DR: Molecular insights into the formation of new blood vessels are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated.
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Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
TL;DR: A growth factor for vascular endothelial cells identified in the media conditioned by bovine pituitary follicular cells and purified to homogeneity by a combination of ammonium sulfate precipitation, heparin-sepharose affinity chromatography and two reversed phase HPLC steps is proposed to be named VGF on the basis of its apparent target cell selectivity.
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The vascular endothelial growth factor family of polypeptides.
TL;DR: Ligand autoradiography on rat tissue sections demonstrates that VEGF binding sites are associated with vascular endothelial cells of both fenestrated and non‐fenestrated capillaries and with the endothelium of large vessels, while no displaceable binding is evident on non‐endothelial cells.