Journal ArticleDOI
Synthesis of substituted 3-arylpiperidines and 3-arylpyrrolidines by radical 1,4 and 1,2-aryl migrations
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TLDR
In this article, a route to 3-arylpiperidines involving radical 1,4-and 1,2-aryl migrations has been explored, which requires a xanthate addition to an N-allylarylsulfonamide, followed by acetylation and treatment with lauroyl peroxide.About:
This article is published in Tetrahedron.The article was published on 2007-07-23. It has received 26 citations till now. The article focuses on the topics: Xanthate & Piperidine.read more
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Journal ArticleDOI
Radical aryl migration reactions and synthetic applications.
TL;DR: This review will give an overview of various types of radical aryl migrations, with an emphasis on their mechanistic studies from a historical point of view, as well as their application in tandem radical reactions.
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Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets
TL;DR: Recent advances regarding the synthetic chemistry of fluorinated aziridine, azetidines, pyrrolidines and their lactam/amino acid counterparts are presented.
Journal ArticleDOI
Applications of allylamines for the syntheses of aza-heterocycles ☆
Somnath Nag,Sanjay Batra +1 more
TL;DR: In this article, a review of the literature concerning the utility of allylamine or substituted allylamines for the synthesis of aza-heterocycles is presented, including nucleophilic reactions, lactamizations, cycloadditions, free radical reactions, cross-couplings and reductive cyclizations.
Journal ArticleDOI
Desulfonylation via Radical Process: Recent Developments in Organic Synthesis.
TL;DR: Recently, sulfonyl-containing compounds and their variants have been merged with various types of reactions for the efficient construction of diverse molecular architectures by taking advantage of their incredible reactive flexibility as mentioned in this paper.
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Radical-mediated rearrangements: past, present, and future.
TL;DR: Radical-mediated rearrangement reactions, one of the most significant transformations in organic chemistry, play an irreplaceable role in improving synthetic efficiency and molecular complexity. as discussed by the authors provides a comprehensive perspective on the area from the past to present achievements, and brings up the prospects that may inspire colleagues to develop more useful synthetic tools based on radical rearrangements.
References
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Book
Organofluorine chemistry : principles and commercial applications
TL;DR: In this paper, Carwright et al. present a survey of recent developments in Fluorine-Containing Agrochemicals and their application in the field of textiles.
BookDOI
Radicals in Organic Synthesis
Philippe Renaud,Mukund P. Sibi +1 more
TL;DR: In this article, the authors discuss the properties of radical chain reactions, single electron properties of radicals, and applications of radical rearrangements in total synthesis, and biomaterials.
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Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog
Thomas F. Spande,H. M. Garraffo,M. W. Edwards,Herman J. C. Yeh,Lewis K. Pannell,John W. Daly +5 more
TL;DR: A potent non-opioid analgesic, epibatidine, has been isolated from skins of the Ecuadoran poison frog, Epipedobates tricolor, and its structure determined by MS, IR, and 1 H NMR analyses as exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane represents a unique new class of alkaloids.
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Trifluoromethylations and related reactions in organic chemistry
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CF3-bearing aromatic and heterocyclic building blocks
TL;DR: Fluorine remains an insiders' tip in the life sciences as it enables the fine-tuning of biological properties and universal methods that are applicable by both industrial and academic researchers thus have great appeal.