Systematic Review of the Socioeconomic Consequences in Patients With Multiple Sclerosis With Different Levels of Disability and Cognitive Function
Reads0
Chats0
TLDR
In this paper , a systematic review on socioeconomic consequences of MS with a focus on employment-, income-, work ability-, and relationship-related outcomes in persons with MS with special focus on disability and cognition was conducted.Abstract:
Multiple sclerosis (MS) is a challenging and disabling condition, predominantly affecting individuals in early adulthood. MS affects the physical, cognitive, and mental health of persons suffering from the disease as well as having a great impact on their financial status and quality of life. However, there is a lack of systematic approach toward assessing the socioeconomic consequences of MS. Our objective was to systematically review analytical observational studies investigating the socioeconomic consequences in persons with MS with different levels of physical disability and cognitive function. We conducted a systematic review on socioeconomic consequences of MS with a focus on employment-, income-, work ability-, and relationship-related outcomes in persons with MS with special focus on disability and cognition. Additionally, the educational characteristics were examined. From 4,957 studies identified, 214 were assessed for eligibility and a total of 19 studies were included in this qualitative assessment; 21 different outcomes were identified. All identified studies reported higher unemployment, higher early retirement, and higher risk of unemployment in relation to higher physical disability. Also, cognitive function was found to be a predictor of employment (unemployment). The studies pointed out significant correlations between greater disability and lower earnings and higher income from benefits. A study found the same correlation in relation to cognitive function. The studies reported higher work disability in relation to higher physical disability and lower cognitive function. In conclusion, this systematic review summarizes the pronounced differences in various socioeconomic outcomes between patients with MS with regards to their physical disability and cognitive function. In addition, we identified a lack of studies with longitudinal design in this field that can provide more robust estimates with covariate adjustments, such as disease modifying treatments.read more
Citations
More filters
Journal ArticleDOI
Social determinants of health in multiple sclerosis
Ruth Dobson,Dylan R. Rice,Marie B. D'hooghe,Rachel Horne,Yvonne C. Learmonth,Farrah J. Mateen,Claudia H Marck,Saúl Reyes,Mitzi J. Williams,Gavin Giovannoni,Helen Ford +10 more
TL;DR: In this article , the authors discuss the potential effects of social determinants of health on multiple sclerosis risk and outcomes, and suggest that addressing these determinants could substantially improve the lives of individuals with multiple sclerosis and call for more research.
Journal ArticleDOI
Prevalence of fatigue and its explicative variables among people with multiple sclerosis.
TL;DR: The present study confirms that physical activity and fatigue are associated and activity-oriented health policies should be redesigned to improve fatigue among French PwMS.
Journal ArticleDOI
What would improve MS clinic services for cognition? - A stakeholder panel and survey exploration.
TL;DR: In this paper , the authors present a cognition handbook for MS clinics, summarising practical information to help the MS multidisciplinary team improve care for PwMS who have cognitive difficulties.
Journal ArticleDOI
RNA‐binding proteins in autoimmunity: From genetics to molecular biology
TL;DR: In this article , the authors reviewed the genetics and molecular biology of RBPs in four major ADs, including multiple sclerosis (MS), type 1 diabetes mellitus (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA).
Journal ArticleDOI
Adrenoceptors as potential target for add-on immunomodulatory therapy in multiple sclerosis.
TL;DR: A review of the role of the sympathetic nervous system (SNS) in pathogenesis of multiple sclerosis and its commonly used experimental model - experimental autoimmune encephalomyelitis (EAE) can be found in this article .
References
More filters
Journal Article
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement [in Spanish]
David Moher,Alessandro Liberati,Jennifer Tetzlaff,Douglas G. Altman,Gerd Antes,David C. Atkins,Virginia Barbour,N Barrowman,Jesse A. Berlin,J Clark,Mike Clarke,Deborah J. Cook,Roberto D'Amico,Jonathan J Deeks,Philip J. Devereaux,Kay Dickersin,M Egger,E Ernst,P C Gøtzsche,Jeremy M. Grimshaw,G Guyatt,Julian P T Higgins,Ioannidis Jpa.,Jos Kleijnen,Tom Lang,N Magrini,D McNamee,Lorenzo Moja,C Mulrow,M Napoli,Andrew D Oxman,B Pham,Drummond Rennie,Margaret Sampson,Kenneth F. Schulz,Paul G. Shekelle,David Tovey,Peter Tugwell +37 more
Journal ArticleDOI
Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
TL;DR: A new Expanded Disability Status Scale (EDSS) is presented, with each of the former steps (1,2,3 … 9) now divided into two (1.0, 1.5, 2.0 … 9).
Journal ArticleDOI
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies
E von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The STROBE Statement is a checklist of items that should be addressed in articles reporting on the 3 main study designs of analytical epidemiology: cohort, casecontrol, and cross-sectional studies; these recommendations are not prescriptions for designing or conducting studies.
Journal ArticleDOI
Immunopathology of multiple sclerosis
TL;DR: The current understanding of multiple sclerosis immunopathology is discussed, long-standing hypotheses regarding the role of the immune system in the disease are evaluated, and key questions that are still unanswered are delineated.
Journal ArticleDOI
Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition.
Clare Walton,Rachel King,Lindsay Rechtman,Wendy Kaye,Emmanuelle Leray,Ruth Ann Marrie,Neil Robertson,Nicholas La Rocca,Bernard M. J. Uitdehaag,Ingrid van der Mei,Mitchell T. Wallin,Anne Helme,Ceri Angood Napier,Nick Rijke,Peer Baneke +14 more
TL;DR: The global prevalence of MS has risen since 2013, but good surveillance data is not universal, and action is needed by multiple stakeholders to close knowledge gaps.