Journal ArticleDOI
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
TLDR
Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate in the brain.Abstract:
Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.read more
Citations
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Inositol trisphosphate and diacylglycerol as second messengers.
Journal ArticleDOI
Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
TL;DR: These findings raise new questions regarding the safety of these agents in the clinical management of neurodegenerative diseases and reinforce concerns about the potential risks associated with illicit use of PCP.
Journal ArticleDOI
Neural and developmental actions of lithium: A unifying hypothesis
TL;DR: Lithium, with an atomic weight of 6.9, is the smallest of the alkali metals, yet this simple ion can exert a profound effect on both human behavior and early embryonic devel- opment.
Journal ArticleDOI
The pilocarpine model of temporal lobe epilepsy.
TL;DR: It is proposed that the pilocarpine model can be a valuable tool to investigate the mechanisms involved in TLE, and even more so when standardized to reduce mortality at the time of pilocARPine injection, differences in latent period duration, variability in the lesion extent, and SRS frequency.
Journal ArticleDOI
Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy
Lechoslaw Turski,Chrysanthy Ikonomidou,Waldemar A. Turski,Zuner A. Bortolotto,Esper A. Cavalheiro +4 more
TL;DR: The amygdala, thalamus, olfactory cortex, hippocampus, neocortex, and substantia nigra are the most sensitive regions to epilepsy‐related damage following convulsions produced by pilocarpine.
References
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Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Journal ArticleDOI
The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.
L.M. Hallcher,W.R. Sherman +1 more
TL;DR: The effects of cholinergic agonists and antagonists on the enzyme were examined and found none and the possibility that the inhibition of this enzyme by lithium ion is related to the pharmacological actions of lithium is discussed.
Journal ArticleDOI
Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system
TL;DR: The close correspondence in molecular specificities associated with neurotoxic and neuroexcitatory properties of simple amino acids suggests the two phenomena may be governed by similar mechanisms of action.