Journal ArticleDOI
Target recognition, resistance, immunity and genome mining of class II bacteriocins from Gram-positive bacteria.
Morten Kjos,Juan Borrero,Mona Opsata,Dagim Jirata Birri,Helge Holo,Luis M. Cintas,Lars Snipen,Pablo E. Hernández,Ingolf F. Nes,Dzung B. Diep +9 more
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TLDR
This review discusses some important recent progress in these areas for the non-lantibiotic (class II) bacteriocins and discusses some examples of how the current wealth of genome sequences provides an invaluable source in the search for novel class II bacteriOCins.Abstract:
Due to their very potent antimicrobial activity against diverse food-spoiling bacteria and pathogens and their favourable biochemical properties, peptide bacteriocins from Gram-positive bacteria have long been considered promising for applications in food preservation or medical treatment. To take advantage of bacteriocins in different applications, it is crucial to have detailed knowledge on the molecular mechanisms by which these peptides recognize and kill target cells, how producer cells protect themselves from their own bacteriocin (self-immunity) and how target cells may develop resistance. In this review we discuss some important recent progress in these areas for the non-lantibiotic (class II) bacteriocins. We also discuss some examples of how the current wealth of genome sequences provides an invaluable source in the search for novel class II bacteriocins.read more
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Bacteriocins — a viable alternative to antibiotics?
TL;DR: Although the application of specific bacteriocins might be curtailed by the development of resistance, an understanding of the mechanisms by which such resistance could emerge will enable researchers to develop strategies to minimize this potential problem.
Journal ArticleDOI
Bacteriocins of lactic acid bacteria: extending the family
TL;DR: This review focuses on the various types of bacteriocins that can be found in LAB and the organization and regulation of the gene clusters responsible for their production and biosynthesis, and considers the food applications of the prototype bacteriOCins from LAB.
Journal ArticleDOI
Emergence of Epidemic Multidrug-Resistant Enterococcus faecium from Animal and Commensal Strains
Francois Lebreton,Francois Lebreton,Willem van Schaik,Willem van Schaik,Willem van Schaik,Abigail Manson McGuire,Paul A. Godfrey,Allison D. Griggs,Varun Mazumdar,Jukka Corander,Lu Cheng,Sakina Saif,Sarah Young,Qiandong Zeng,Jennifer R. Wortman,Bruce W. Birren,Rob J. L. Willems,Ashlee M. Earl,Michael S. Gilmore,Michael S. Gilmore +19 more
TL;DR: The epidemic hospital-adapted lineage is rapidly evolving and emerged approximately 75 years ago, concomitant with the introduction of antibiotics, from a population that included the majority of animal strains, and not from human commensal lines.
Journal ArticleDOI
Natural antimicrobial peptides from bacteria: characteristics and potential applications to fight against antibiotic resistance.
TL;DR: The emerging antibiotic resistance and strategies to control its dissemination are discussed, before the potential of AMPs from bacteria are highlighted as a new genre of antimicrobial agents.
Journal ArticleDOI
Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations
Samira Soltani,Riadh Hammami,Paul D. Cotter,Paul D. Cotter,Sylvie Rebuffat,Laila Ben Said,Hélène Gaudreau,François Bédard,Eric Biron,Djamel Drider,Ismail Fliss +10 more
TL;DR: Although bacteriocins have been predominantly exploited as food preservatives, they are now receiving increased attention as potential clinical antimicrobials and as possible immune-modulating agents.
References
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Prodigal: prokaryotic gene recognition and translation initiation site identification
Doug Hyatt,Doug Hyatt,Gwo Liang Chen,Philip F. LoCascio,Miriam Land,Frank W. Larimer,Frank W. Larimer,Loren Hauser +7 more
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Journal ArticleDOI
Bacteriocins of gram-positive bacteria.
TL;DR: A group of antibacterial proteins produced by gram-positive bacteria have attracted great interest in their potential use as food preservatives and as antibacterial agents to combat certain infections due to gram- positive pathogenic bacteria.
Journal ArticleDOI
Bacteriocins: developing innate immunity for food
TL;DR: Bacteriocins are bacterially produced antimicrobial peptides with narrow or broad host ranges that can be used to confer a rudimentary form of innate immunity to foodstuffs, helping processors extend their control over the food flora long after manufacture.
Journal ArticleDOI
Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.
TL;DR: The IIAGlc protein, part of the glucose-specific PTS, is a central regulatory protein which in its nonphosphorylated form can bind to and inhibit several non-PTS uptake systems and thus prevent entry of inducers.