TGF-beta family signal transduction in Drosophila development: from Mad to Smads.
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TLDR
Genetic studies in Drosophila are now expanding to include multiple BMP ligands and receptors and have uncovered activities not explained by the current signal transduction model, suggesting that all TGF-beta signalTransduction pathways are present in flies.About:
This article is published in Developmental Biology.The article was published on 1999-06-15 and is currently open access. It has received 347 citations till now. The article focuses on the topics: SMAD & Mothers against decapentaplegic homolog 2.read more
Citations
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Smad transcription factors
TL;DR: The growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior.
Journal ArticleDOI
Tgfbeta signaling in growth control, cancer, and heritable disorders
TL;DR: The author would like to thank S. H. Roan for all her help and members of the Massague laboratory for insightful discussions.
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How cells read TGF-beta signals.
TL;DR: The TGF-β family of cytokines can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell.
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Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators.
Wendy Balemans,Wim Van Hul +1 more
TL;DR: The insights in the extracellular regulation of members of the BMP subfamily of secreted growth factors with a major emphasis on vertebrate BMP modulation are reviewed.
References
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TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
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An Empirical Test of Bootstrapping as a Method for Assessing Confidence in Phylogenetic Analysis
David M. Hillis,James J. Bull +1 more
TL;DR: This work uses computer simulations and a laboratory-generated phylogeny to test bootstrapping results of parsimony analyses, and indicates that any given bootstrap proportion provides an unbiased but highly imprecise measure of repeatability, unless the actual probability of replicating the relevant result is nearly one.
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Novel regulators of bone formation: molecular clones and activities.
John M. Wozney,Vicki Rosen,Anthony J. Celeste,Lisa M. Mitsock,Matthew J. Whitters,Ronald W. Kriz,Rodney M. Hewick,Elizabeth A. Wang +7 more
TL;DR: Human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained, and each appears to be independently capable of inducing the formation of cartilage in vivo.
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DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Stephan A. Hahn,Mieke Schutte,A. T. M. Shamsul Hoque,Christopher A. Moskaluk,Luis T. da Costa,Ester Rozenblum,C. L. Weinstein,Aryeh Fischer,Charles J. Yeo,Ralph H. Hruban,Scott E. Kern +10 more
TL;DR: DPC4 is identified as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.
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Mechanism of activation of the TGF-β receptor
TL;DR: The role of TGF-β binds directly to receptor II, which is a constitutively active kinase, and phosphorylation allows receptor I to propagate the signal to downstream substrates, providing a mechanism by which a cytokine can generate the first step of a signalling cascade.