Journal ArticleDOI
How cells read TGF-beta signals.
TLDR
The TGF-β family of cytokines can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell.Abstract:
Cell proliferation, differentiation and death are controlled by a multitude of cell-cell signals, and loss of this control has devastating consequences Prominent among these regulatory signals is the transforming growth factor-beta (TGF-beta) family of cytokines, which can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell What are the networks of cell-specific molecules that mould the TGF-beta response to each cell's needs?read more
Citations
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Journal ArticleDOI
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Yigong Shi,Joan Massagué +1 more
TL;DR: Current understanding on the mechanisms of TGF-β signaling from cell membrane to the nucleus is presented and the transcriptional regulation of target gene expression is reviewed.
Journal ArticleDOI
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Rik Derynck,Ying E. Zhang +1 more
TL;DR: Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis, and combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smadracing proteins, and cooperation with sequence-specific transcription factors allow substantial versatility and diversification of TGF- β family responses.
Journal ArticleDOI
TGFβ signalling in context.
TL;DR: The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed and the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings.
Journal ArticleDOI
TGF-beta signaling in tumor suppression and cancer progression.
TL;DR: The role of TGF-β is evaluated as both a tumor suppressor pathway and a promoter of tumor progression and invasion and the positive and negative effects of T GF-β in carcinogenesis are attempted.
Journal ArticleDOI
RAS oncogenes: weaving a tumorigenic web
TL;DR: This Review describes how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.
References
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Journal ArticleDOI
TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
Journal ArticleDOI
Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Toshihisa Komori,Hideshi Yagi,Shintaro Nomura,Akira Yamaguchi,Koichi Sasaki,Kenji Deguchi,Y Shimizu,Roderick T. Bronson,Y.-H Gao,Masahiko Inada,Makoto Sato,R Okamoto,Yukihiko Kitamura,Shusaku Yoshiki,Tadamitsu Kishimoto +14 more
TL;DR: The data suggest that both intramembranous and endochondral ossification were completely blocked, owing to the maturational arrest of osteoblasts in the mutant mice, and demonstrate that Cbfa1 plays an essential role in osteogenesis.
Journal ArticleDOI
Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development
Florian Otto,Anders P Thornell,Tessa Crompton,Angela Denzel,Kimberly C Gilmour,Ian R Rosewell,Gordon Stamp,Rosa S.P Beddington,Stefan Mundlos,Bjorn R. Olsen,Paul B. Selby,Michael John Owen +11 more
TL;DR: The Cbfa1 gene is essential for osteoblast differentiation and bone formation, and the C bfa1 heterozygous mouse is a paradigm for a human skeletal disorder.
Journal ArticleDOI
DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Stephan A. Hahn,Mieke Schutte,A. T. M. Shamsul Hoque,Christopher A. Moskaluk,Luis T. da Costa,Ester Rozenblum,C. L. Weinstein,Aryeh Fischer,Charles J. Yeo,Ralph H. Hruban,Scott E. Kern +10 more
TL;DR: DPC4 is identified as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.
Journal ArticleDOI
Tgfbeta signaling in growth control, cancer, and heritable disorders
TL;DR: The author would like to thank S. H. Roan for all her help and members of the Massague laboratory for insightful discussions.
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Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
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