The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives.
Liwei Fu,Pinxue Li,Pinxue Li,Hao Li,Hao Li,Cangjian Gao,Cangjian Gao,Zhen Yang,Zhen Yang,Tianyuan Zhao,Tianyuan Zhao,Wei Chen,Wei Chen,Zhiyao Liao,Zhiyao Liao,Yu Peng,Fuyang Cao,Xiang Sui,Shuyun Liu,Quanyi Guo,Quanyi Guo +20 more
TLDR
An overview of the concepts, categories, and applications of bioreactors for cartilage TE with emphasis on the design of various bioreactor systems can be found in this article,.Abstract:
Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of TE; what most important is that static cell culture on scaffolds cannot simulate the physiological environment required for the development of natural cartilage. Recently, bioreactors have been used to simulate the physical and mechanical environment during the development of articular cartilage. This review aims to provide an overview of the concepts, categories, and applications of bioreactors for cartilage TE with emphasis on the design of various bioreactor systems.read more
Citations
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Hydrogel composite scaffolds achieve recruitment and chondrogenesis in cartilage tissue engineering applications
Bo Huang,Pinxue Li,Mingxue Chen,Liqing Peng,Xujiang Luo,Guangzhao Tian,Lei Wu,Qinyu Tian,Huo Li,Yu Yang,Shuangpeng Jiang,Zhen Yang,Kangkang Zha,Xiang Sui,Shuyun Liu,Quanyi Guo +15 more
TL;DR: Wang et al. as discussed by the authors constructed a skeleton-based scaffold that can be easily molded to fill cartilage defects of any shape that fit tightly into the host cartilage, and the skeleton provided a three-dimensional microenvironment supporting cell adhesion, proliferation and chondrogenic differentiation.
Journal ArticleDOI
Cell therapy for cartilage repair.
Charlotte H Hulme,Charlotte H Hulme,Jade Perry,Jade Perry,Helen S. McCarthy,Helen S. McCarthy,Karina T. Wright,Karina T. Wright,Martyn Snow,Claire Mennan,Claire Mennan,Sally Roberts,Sally Roberts +12 more
TL;DR: The main cell types used in treating chondral or osteochondral defects in joints to date are chondrocytes and mesenchymal stromal cells derived from various sources such as bone marrow, adipose tissue or umbilical cord as mentioned in this paper.
Journal ArticleDOI
Biomedical Applications of Microfluidic Devices: A Review
Ghazaleh Gharib,Wai Ching Sin +1 more
TL;DR: A comprehensive overview of the significant advances that have been made in the development of microfluidics devices is provided in this article , where the authors discuss the function of micro-fluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping).
Journal ArticleDOI
Hydrogels in the treatment of rheumatoid arthritis: drug delivery systems and artificial matrices for dynamic in vitro models
Isabel Maria Oliveira,Diogo Castro Fernandes,Ibrahim Fatih Cengiz,Rui L. Reis,Joaquim M. Oliveira +4 more
TL;DR: In this article, the use of hydrogels as artificial extracellular matrices in dynamic in vitro articular cartilage is also reviewed for the treatment of Rheumatoid arthritis.
Journal ArticleDOI
Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review
TL;DR: The application of advanced tissue engineering techniques provides hope for the researchers to recognize COVID-19/host interaction, also, it presents a promising solution to rejuvenate the destroyed lung tissues.
References
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