Journal ArticleDOI
The applications of Vitamin E TPGS in drug delivery.
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TLDR
TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, adjuvant in vaccine systems, nutrition supplement, plasticizer of film, anticancer reagent and so on are discussed.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2013-05-13. It has received 437 citations till now. The article focuses on the topics: Drug delivery.read more
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Progress in the study of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) reversing multidrug resistance.
TL;DR: In this paper, the authors summarize the latest articles on TPGS-based nanodelivery systems to prevent multidrug resistance (MDR) in clinical cancer chemotherapy.
Journal ArticleDOI
Vitamin E TPGS based palatable, oxidatively and physically stable emulsion of microalgae DHA oil for infants, children and food fortification
Harmanpreet Singh,Jasvinder Singh,Shashank K. Singh,Narpinder Singh,Surinder Paul,Harminder Singh Sohal,Umesh Gupta,Subheet Kumar Jain +7 more
TL;DR: Improved in vivo pharmacodynamic activity and 1.4 folds increase in bioavailability in comparison to DHA oil during the pharmacokinetic study was observed, demonstrating the better bioavailability of Vitamin E TPGS based emulsion formulation.
Journal ArticleDOI
Formulation Design, Optimization and In Vivo Evaluations of an α-Tocopherol-Containing Self-Emulsified Adjuvant System using Inactivated Influenza Vaccine.
Rushit N. Lodaya,Amey P. Kanitkar,Kristian Friedrich,Dawn Henson,Ryan Yamagata,Sandra Nuti,Corey P. Mallett,Sylvie Bertholet,Mansoor M. Amiji,Derek T. O'Hagan +9 more
TL;DR: This study created novel self-emulsified adjuvant systems (SE-AS) and evaluated their potency in vivo in BALB/c mice with inactivated quadrivalent influenza vaccine (QIV) and tested the cellular and humoral immune responses against the four vaccine strains.
Journal ArticleDOI
Iron Transport Tocopheryl Polyethylene Glycol Succinate in Animal Health and Diseases
TL;DR: The ITPGS approach appears to be a novel strategy for maintaining the health of animals by manipulation of microbiota and presents a novel approach to increase the bioavailability of drugs, phytoconstituents, nutrients, and nanomedicines by enhanced transport to the tissues at the site of action.
Journal ArticleDOI
A promising targeting system to enrich irinotecan antitumor efficacy: Folic acid targeted nanoparticles
Borhaneh Hasan-Nasab,Pedram Ebrahimnejad,Pouneh Ebrahimi,Faezeh Sharifi,Maryam Salili,Fatemeh Shahlaee,Ali Nokhodchi +6 more
TL;DR: In this article, the authors used the Box-Behnken design to determine the combined impact of independent variables for choosing the appropriate formulation of folic acid-polyethylene glycol -poly lactic-co-glycolic acid.
References
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Journal Article
Heart-lung transplantation.
TL;DR: A broad overview of the various grounds upon which this difference is likely based and discuss recent advances in each area: 1) criteria for the selection of candidates and donors, 2) methods for ex-vivo preservation of donor organs, 3) technical execution of the operative procedure, and 4) prevention of postoperative infection as discussed by the authors.
Journal ArticleDOI
Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.
TL;DR: Stealth liposomes can be actively targeted with monoclonal antibodies or ligands and encapsulating active molecules, with high target efficiency and activity by synthetic modification of the terminal PEG molecule.
Journal ArticleDOI
Solubilizing excipients in oral and injectable formulations.
TL;DR: The chemical techniques to solubilize water-insoluble drugs for oral and injection administration include pH adjustment, cosolvents, complexation, microemulsions, self-emulsifying drug delivery systems, micelles, liposomes, and emulsions.
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Vitamin E TPGS as a molecular biomaterial for drug delivery
TL;DR: TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles.
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Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.
TL;DR: The results suggest that surfactants can inhibit multiple transporters but that changes in membrane fluidity may not be a generalized mechanism to reduce transporter activity.