Journal ArticleDOI
The applications of Vitamin E TPGS in drug delivery.
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TLDR
TPGS properties as a P-gp inhibitor, solubilizer/absorption and permeation enhancer in drug delivery and TPGS-related formulations such as nanocrystals, nanosuspensions, tablets/solid dispersions, adjuvant in vaccine systems, nutrition supplement, plasticizer of film, anticancer reagent and so on are discussed.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2013-05-13. It has received 437 citations till now. The article focuses on the topics: Drug delivery.read more
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Effect of hydrophilic additives on the dissolution and pharmacokinetic properties of itraconazole-enteric polymer hot-melt extruded amorphous solid dispersions
TL;DR: Investigation of the effect of hydrophilic additives on the in vitro and in vivo performance of ITZ-enteric polymer amorphous solid dispersions found that Vitamin E TPGS induced rapid drug absorption after oral administration significantly improved drug release in the acidic media.
Journal ArticleDOI
Preparation and evaluation of celecoxib nanosuspensions for bioavailability enhancement
TL;DR: Wang et al. as mentioned in this paper used D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as stabilizer via high pressure homogenization (HPH) and then freeze-dried to solid powder.
Journal ArticleDOI
Enabling Oral SN38-Based Chemotherapy with a Combined Lipophilic Prodrug and Self-Microemulsifying Drug Delivery System
TL;DR: The combination of lipophilic prodrug along with an optimal delivery carrier is demonstrated to enable effective oral delivery of challenging chemotherapeutic compounds that are conventionally dosed by injection.
Journal ArticleDOI
Microglial trogocytosis and the complement system regulate axonal pruning in vivo
Tony K.Y. Lim,Edward S. Ruthazer +1 more
TL;DR: In this paper, the authors show that microglia regulate axon trogocytosis via complement activation 3, a homolog of human CD46, in the developing Xenopus laevis retinotectal circuit.
Journal ArticleDOI
Rational design of protamine nanocapsules as antigen delivery carriers
José Vicente González-Aramundiz,José Vicente González-Aramundiz,Elena Presas,Inmaculada Dalmau-Mena,Susana Martínez-Pulgarín,Covadonga Alonso,José M. Escribano,María J. Alonso,Noemi Csaba +8 more
TL;DR: In vivo studies indicate that antigen‐loaded nanocapsules trigger immune responses comparable to those achieved with alum, even when using significantly lower antigen doses, thus indicating their adjuvant properties.
References
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Journal Article
Heart-lung transplantation.
TL;DR: A broad overview of the various grounds upon which this difference is likely based and discuss recent advances in each area: 1) criteria for the selection of candidates and donors, 2) methods for ex-vivo preservation of donor organs, 3) technical execution of the operative procedure, and 4) prevention of postoperative infection as discussed by the authors.
Journal ArticleDOI
Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential.
TL;DR: Stealth liposomes can be actively targeted with monoclonal antibodies or ligands and encapsulating active molecules, with high target efficiency and activity by synthetic modification of the terminal PEG molecule.
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Solubilizing excipients in oral and injectable formulations.
TL;DR: The chemical techniques to solubilize water-insoluble drugs for oral and injection administration include pH adjustment, cosolvents, complexation, microemulsions, self-emulsifying drug delivery systems, micelles, liposomes, and emulsions.
Journal ArticleDOI
Vitamin E TPGS as a molecular biomaterial for drug delivery
TL;DR: TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles.
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Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.
TL;DR: The results suggest that surfactants can inhibit multiple transporters but that changes in membrane fluidity may not be a generalized mechanism to reduce transporter activity.