Journal ArticleDOI
The asymmetric intramolecular Heck reaction in natural product total synthesis.
Amy B. Dounay,Larry E. Overman +1 more
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This article is published in Chemical Reviews.The article was published on 2003-07-08. It has received 1247 citations till now. The article focuses on the topics: Heck reaction & Total synthesis.read more
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Palladium(II)/Cationic 2,2’-Bipyridyl System as a Highly Efficient and Reusable Catalyst for the Mizoroki-Heck Reaction in Water
TL;DR: A water-soluble and air-stable Pd(NH3)2Cl2/cationic 2,2’-bipyridyl system was found to be a highly-efficient and reusable catalyst for the coupling of aryl iodides and alkenes in neat water using Bu3N as a base, providing the corresponding products in good to excellent yields with very high turnover numbers.
Journal ArticleDOI
Construction of Quaternary Stereocenters by Nickel-Catalyzed Heck Cyclization Reactions.
Jean-Nicolas Desrosiers,Liana Hie,Soumik Biswas,Olga V. Zatolochnaya,Sonia Rodriguez,Heewon Lee,Nelu Grinberg,Nizar Haddad,Nathan K. Yee,Neil K. Garg,Chris H. Senanayake +10 more
TL;DR: A nickel-catalyzed Heck cyclization for the construction of quaternary stereocenters is reported, which provides a rare means to construct stereochemically complex frameworks by nonprecious-metal catalysis.
Journal ArticleDOI
Palladium-catalyzed alkenation of thiophenes and furans by regioselective C–H bond functionalization
TL;DR: A palladium-catalyzed direct alkenation of thiophenes and furans has been developed in the presence of AgOAc and pyridine as discussed by the authors, where the (E)-isomers were isolated as the major products.
Journal ArticleDOI
Phosphine‐Catalyzed Asymmetric [4+2] Annulation of Vinyl Ketones with Oxindole‐Derived α,β‐Unsaturated Imines: Enantioselective Syntheses of 2′,3′‐Dihydro‐1′H‐spiro[indoline‐3,4′‐pyridin]‐2‐ones
Journal ArticleDOI
CuI/Dabco as a highly active catalytic system for the Heck-type reaction
TL;DR: In this article, an efficient catalytic system using CuI/Dabco (triethylenediamine) for the Heck-type cross-coupling reaction was developed.
References
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BookDOI
Metal-catalyzed cross-coupling reactions
TL;DR: In this paper, the authors present an approach to the formation of C-X (X = N, O, S) bonds in metal-catalyzed cross-coupling reactions.
Journal ArticleDOI
The heck reaction as a sharpening stone of palladium catalysis.
TL;DR: s, or keywords if they used Heck-type chemistry in their syntheses, because it became one of basic tools of organic preparations, a natural way to make organic preparations.
Book
Catalytic Asymmetric Synthesis
TL;DR: Asymmetric Hydrogenation (T. Ohkuma, et al. as discussed by the authors ), asymmetric carbon-Carbon Bond-Forming Reactions (K. Nozaki & I. Negishi). Asymmetric Addition and Insertion Reactions of Catalytically-Generated Metal Carbenes (M. O'Donnell), and asymptotic phase-transfer Reactions.
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The heck reaction as a sharpening stone of palladium catalysis.
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Richard F. Heck,J. P. Nolley +1 more