Journal ArticleDOI
The asymmetric intramolecular Heck reaction in natural product total synthesis.
Amy B. Dounay,Larry E. Overman +1 more
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This article is published in Chemical Reviews.The article was published on 2003-07-08. It has received 1247 citations till now. The article focuses on the topics: Heck reaction & Total synthesis.read more
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A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media
TL;DR: A simple and eco-friendly method for the aminomethylation of various 3-substituted oxindoles via three-component Mannich reaction in aqueous media has been established and particularly valuable features are embodied in this method.
Journal ArticleDOI
Palladium-Catalyzed Enantioselective 7-exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzo[b,d]azepin-6-ones
Huaanzi Hu,Huaanzi Hu,Yan Peng,Yan Peng,Ting Yu,Ting Yu,Sidi Cheng,Sidi Cheng,Shuang Luo,Shuang Luo,Qiang Zhu +10 more
TL;DR: In this article, a series of 7-acetate- or 7acetamide-substituted dibenzo[b,d]azepin-6-ones were obtained under atmospheric pressure of CO in good yields with excellent diastereo and enantioselectivities.
Journal ArticleDOI
Palladium-Catalyzed Domino Reaction for Stereoselective Synthesis of Multisubstituted Olefins: Construction of Blue Luminogens.
Taotao Hao,Haoran Liang,Ying-Han Ou-Yang,Changzhen Yin,Xueli Zheng,Maolin Yuan,Ruixiang Li,Haiyan Fu,Hua Chen +8 more
TL;DR: The first Pd-catalyzed multicomponent reaction of aryl iodides, alkenyl bromides, and strained alkenes has been developed, which allowed us to synthesize a variety of multisubsituted olefins in yields of 45-96% with excellent stereoselectivity.
Journal ArticleDOI
Mechanistic Investigation of the Pd-Catalyzed Intermolecular Carboetherification and Carboamination of 2,3-Dihydrofuran: Similarities, Differences, and Evidence for Unusual Reaction Intermediates
TL;DR: In this paper, the mechanism of the Pd-catalyzed intermolecular syn carboetherification and carboamination of 2,3-dihydrofuran was investigated experimentally.
Journal ArticleDOI
Imidazolidinone based chiral auxiliary mediated acetate aldol reactions of isatin derivatives and stereoselective synthesis of 3-substituted-3-hydroxy-2-oxindoles
TL;DR: In this paper, the (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one chiral auxiliary has been optimized with high yields and diastereoselectivity on various N-substituted isatins.
References
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BookDOI
Metal-catalyzed cross-coupling reactions
TL;DR: In this paper, the authors present an approach to the formation of C-X (X = N, O, S) bonds in metal-catalyzed cross-coupling reactions.
Journal ArticleDOI
The heck reaction as a sharpening stone of palladium catalysis.
TL;DR: s, or keywords if they used Heck-type chemistry in their syntheses, because it became one of basic tools of organic preparations, a natural way to make organic preparations.
Book
Catalytic Asymmetric Synthesis
TL;DR: Asymmetric Hydrogenation (T. Ohkuma, et al. as discussed by the authors ), asymmetric carbon-Carbon Bond-Forming Reactions (K. Nozaki & I. Negishi). Asymmetric Addition and Insertion Reactions of Catalytically-Generated Metal Carbenes (M. O'Donnell), and asymptotic phase-transfer Reactions.
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Richard F. Heck,J. P. Nolley +1 more