Journal ArticleDOI
The asymmetric intramolecular Heck reaction in natural product total synthesis.
Amy B. Dounay,Larry E. Overman +1 more
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This article is published in Chemical Reviews.The article was published on 2003-07-08. It has received 1247 citations till now. The article focuses on the topics: Heck reaction & Total synthesis.read more
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Hybrid Organic‐Inorganic Materials from Di‐(2‐pyridyl)methylamine‐Palladium Dichloride Complex as Recoverable Catalysts for Suzuki, Heck and Sonogashira Reactions
TL;DR: Hybrid silica materials containing the di-(2-pyridyl)methylamine-palladium dichloride complex, prepared by sol-gel cogelification, are efficient recyclable catalysts for Suzuki (aryl bromides and chlorides), Heck and Sonogashira reactions.
Journal ArticleDOI
An Efficient Synthesis of Polysubstituted Pyridines via C sp 3H Oxidation and CS Cleavage of Dimethyl Sulfoxide
TL;DR: An expedient cleavage of the CS bond of dimethyl sulfoxide (DMSO) has been developed for the preparation of substituted pyridines from ketones in high yields and exhibited a broad substrate scope towards a wide variety of different ketones to give the corresponding substitutions.
Journal ArticleDOI
The Quinine Thiourea-Catalyzed Asymmetric Strecker Reaction: An Approach for the Synthesis of 3-Aminooxindoles
Dong Wang,Jinyan Liang,Jingchao Feng,Kairong Wang,Quantao Sun,Long Zhao,Dan Li,Wenjin Yan,Rui Wang,Rui Wang +9 more
TL;DR: This method represents the first enantioselective organocatalyzed Strecker reaction with N-Boc-ketimines as electrophiles and may be the first in the world to employ a quinine-derived thiourea catalyst.
Journal ArticleDOI
Directed Copper-Catalyzed Intermolecular Heck-Type Reaction of Unactivated Olefins and Alkyl Halides
TL;DR: DFT calculations disclosed a dimethyl sulfoxide assisted concerted H-Br elimination process of a conformationally strained Cu(III) cyclic transition state that produced coupled alkyl olefin products with excellent regio- and stereoselectivity.
Journal ArticleDOI
Total synthesis of (+)-asperazine
Steven P. Govek,Larry E. Overman +1 more
TL;DR: The first total synthesis of the structurally novel cyclotryptophan alkaloid asperazine is reported, which confirmed the structure of (+)-asperazine and provided material for additional biological studies.
References
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BookDOI
Metal-catalyzed cross-coupling reactions
TL;DR: In this paper, the authors present an approach to the formation of C-X (X = N, O, S) bonds in metal-catalyzed cross-coupling reactions.
Journal ArticleDOI
The heck reaction as a sharpening stone of palladium catalysis.
TL;DR: s, or keywords if they used Heck-type chemistry in their syntheses, because it became one of basic tools of organic preparations, a natural way to make organic preparations.
Book
Catalytic Asymmetric Synthesis
TL;DR: Asymmetric Hydrogenation (T. Ohkuma, et al. as discussed by the authors ), asymmetric carbon-Carbon Bond-Forming Reactions (K. Nozaki & I. Negishi). Asymmetric Addition and Insertion Reactions of Catalytically-Generated Metal Carbenes (M. O'Donnell), and asymptotic phase-transfer Reactions.
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Richard F. Heck,J. P. Nolley +1 more