The Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
Bruce S. McEwen,John H. Morrison +1 more
TLDR
The prefrontal cortex is involved in working memory and self-regulatory and goal-directed behaviors and displays remarkable structural and functional plasticity over the life course, though such effects are not necessarily permanent, as young animals show remarkable neuronal resilience if the stress is discontinued.About:
This article is published in Neuron.The article was published on 2013-07-10 and is currently open access. It has received 739 citations till now. The article focuses on the topics: Prefrontal cortex & Working memory.read more
Citations
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The neuroscience of mindfulness meditation
TL;DR: Research over the past two decades broadly supports the claim that mindfulness meditation exerts beneficial effects on physical and mental health, and cognitive performance, but the underlying neural mechanisms remain unclear.
Journal ArticleDOI
Mechanisms of stress in the brain
Bruce S. McEwen,Nicole P. Bowles,Jason D. Gray,Matthew N. Hill,Richard G. Hunter,Ilia N. Karatsoreos,Carla Nasca +6 more
TL;DR: The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms.
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Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
TL;DR: Findings in animal models have resulted in translation to the human brain and have helped change thinking about the nature of brain malfunction in psychiatric disorders and during aging, as well as the mechanisms of the effects of early-life adversity on the brain and the body.
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.
TL;DR: An overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health is provided.
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Sex differences and stress across the lifespan
Tracy L. Bale,C. Neill Epperson +1 more
TL;DR: Although stress is involved in a much broader range of diseases than neuropsychiatric ones, this area and its examples across the lifespan are highlighted.
References
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Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study
Vincent J. Felitti,Robert F. Anda,Dale F. Nordenberg,David F. Williamson,Alison M. Spitz,Valerie J. Edwards,Mary P. Koss,James S. Marks +7 more
TL;DR: For example, this article found a strong relationship between the breadth of exposure to abuse or household dysfunction during childhood and multiple risk factors for several of the leading causes of death in adults.
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Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning
R. G. Phillips,Joseph E. LeDoux +1 more
TL;DR: An associative roles for the amygdala and a sensory relay role for the hippocampus are suggested in fear conditioning, which is involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli.
Book
The prefrontal cortex
TL;DR: The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain.
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Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
TL;DR: An oculomotor delayed-response task was used to examine the spatial memory functions of neurons in primate prefrontal cortex and found that inhibitory responses were usually strongest for, or centered about, cue directions roughly opposite those optimal for excitatory responses.
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Subgenual prefrontal cortex abnormalities in mood disorders
Wayne C. Drevets,Joseph L. Price,Joseph R. Simpson,Richard D. Todd,Theodore Reich,Michael W. Vannier,Michael W. Vannier,Marcus E. Raichle +7 more
TL;DR: Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.