Journal ArticleDOI
The effect of high level natural ionizing radiation on expression of PSA, CA19-9 and CEA tumor markers in blood serum of inhabitants of Ramsar, Iran.
Mohammad Hassan Heidari,Mohsen Porghasem,Nazanin Mirzaei,Jafar Hesam Mohseni,Matine Heidari,Eznollah Azargashb,Abolfazl Movafagh,Reihane Heidari,Aidin Molouki,Leila Larijani +9 more
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TLDR
Using an ELISA method, the level of expression of three tumor markers known as carcinoembryonic antigen (CEA), prostate-specific antigen (PSA) and carcino antigen 19-9 (CA19-9) in blood serum of 40 men of Ramsar was investigated and compared to 40 men from the city of Noshahr, which was previously identified as a normal level natural radiation area (NLNRA).About:
This article is published in Journal of Environmental Radioactivity.The article was published on 2014-02-01. It has received 24 citations till now. The article focuses on the topics: Blood serum.read more
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Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen
TL;DR: In this paper, a label-free electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen (CEA) using Ag/MoS2/rGO nanocomposites.
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Ultrasensitive photoelectrochemical immunoassay for CA19-9 detection based on CdSe@ZnS quantum dots sensitized TiO2NWs/Au hybrid structure amplified by quenching effect of Ab2@V(2+) conjugates.
TL;DR: A novel, enhanced photoelectrochemical immunoassay was established for sensitive and specific detection of carbohydrate antigen 19-9 and showed good reproducibility, specificity and stability, and might be applied to detect other important biomarkers.
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A one-step electrochemiluminescence immunosensor preparation for ultrasensitive detection of carbohydrate antigen 19-9 based on multi-functionalized graphene oxide.
TL;DR: This one-step ECL immunosensor showed good performance in specificity, stability, reproducibility, regeneration and application, and opened a new avenue to apply multi-functionalized bionanomaterials in ECL Immunoassay.
Journal ArticleDOI
The linear no-threshold model is less realistic than threshold or hormesis-based models: An evolutionary perspective.
TL;DR: This review reiterates that the LNT model as applied to stochastic biological effects of low and moderate stressor levels has less biological validity than threshold or, particularly, hormetic models.
Journal ArticleDOI
An ultrasensitive multi-walled carbon nanotube–platinum–luminol nanocomposite-based electrochemiluminescence immunosensor
TL;DR: An ultrasensitive electrochemiluminescence (ECL) immunosensor for carbohydrate antigen 19-9 detection using multi-walled carbon nanotube-platinum-luminol nanocomposite as nanointerface and signal tags was designed and provided satisfactory results in the determination of CA19-9 in real human serum samples.
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Journal ArticleDOI
Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques
Phil Gold,Samuel O. Freedman +1 more
TL;DR: It was shown that the tumor-specific antibodies were not directed against bacterial contaminants or against the unusually high concentrations of fibrin found in many neoplastic tissues.
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Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men.
William J. Catalona,Jerome P. Richie,Frederick R. Ahmann,M'Liss A. Hudson,Peter T. Scardino,Robert C. Flanigan,Jean B. deKernion,Timothy L. Ratliff,Louis R. Kavoussi,Bruce L. Dalkin,W. Bedford Waters,Michael T. Macfarlane,Paula C. Southwick +12 more
TL;DR: In this paper, a prospective clinical trial at 6 university centers of 6,630 male volunteers 50 years old or older who underwent PSA determination (Hybritech Tandom-E or Tandem-R assays) and digital rectal examination was conducted.
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Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation
TL;DR: The most important electron acceptor in the biosphere is molecular oxygen which, by virtue of its bi-radical nature, readily accepts unpaired electrons to give rise to a series of partially reduced species collectively known as reduced (or ‘reactive’) oxygen species (ROS).
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The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues.
TL;DR: The human CEA family comprises 29 genes of which 18 are expressed; 7 belonging to the CEA subgroup and 11 to the pregnancy specific glycoprotein subgroup, which shows a complex expression pattern in normal and cancerous tissues with notably CEA showing a selective epithelial expression.