Journal ArticleDOI
The effects of implant surface nanoscale features on osteoblast-specific gene expression.
Gustavo Mendonça,Gustavo Mendonça,Daniela Baccelli Silveira Mendonça,Daniela Baccelli Silveira Mendonça,L. G. P. Simoes,André Luiz Araújo,Edson R. Leite,Wagner R. Duarte,Francisco J. L. Aragão,Lyndon F. Cooper +9 more
Reads0
Chats0
TLDR
N nanostructured surfaces produced using aluminum oxide significantly enhanced the hMSC gene expression representative of osteoblast differentiation, suggesting nanoscale features on Ti implant substrates may improve the osseointegration response by altering adherent cell response.About:
This article is published in Biomaterials.The article was published on 2009-09-01. It has received 226 citations till now. The article focuses on the topics: Nanotopography & Nanostructure.read more
Citations
More filters
Journal ArticleDOI
The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation
Rolando A. Gittens,Taylor McLachlan,Rene Olivares-Navarrete,Ye Cai,Simon Berner,Rina Tannenbaum,Zvi Schwartz,Kenneth H. Sandhage,Barbara D. Boyan +8 more
TL;DR: The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which indicates the potential for improved implant osseointegration in vivo.
Journal ArticleDOI
Classification of osseointegrated implant surfaces: materials, chemistry and topography
TL;DR: A standardized classification system will allow to clarify unambiguously the identity of any given osseointegrated surface and help to identify the biological outcomes of each surface characteristic.
Journal ArticleDOI
Surface characteristics of dental implants: A review.
TL;DR: Different height, spatial, hybrid and functional roughness parameters have been identified as possible candidates able to predict the outcome at hard and soft tissue interfaces and hydrophilic implants have been proven to improve the initial blood contact, to support the wound healing and thereby accelerating the osseointegration.
Journal ArticleDOI
Implant osseointegration and the role of microroughness and nanostructures: Lessons for spine implants
TL;DR: The findings revealed that surface properties such as microroughness and nanostructures can directly affect early cell behavior and long-term osseointegration of implants.
Journal ArticleDOI
Biomedical production of implants by additive electro-chemical and physical processes
Paulo Jorge Da Silva Bartolo,Jean-Pierre Kruth,Jorge Vicente Lopes da Silva,G Levy,G Levy,Ajay P. Malshe,Kamlakar P Rajurkar,Mamoru Mitsuishi,Joaquim Ciurana,Ming C. Leu +9 more
TL;DR: In this paper, the state-of-the-art of this rapidly evolving manufacturing sector is presented and discussed, in particular the additive electrical, chemical and physical processes currently being applied to produce synthetic and biological parts.
References
More filters
Journal ArticleDOI
Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro
TL;DR: In this paper, a reproducible system for the in vitro osteogenic differentiation of human mesenchymal stem cells (MSCs) was presented. But the authors did not consider the effect of changes in the microenvironment upon the process.
Journal ArticleDOI
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
Matthew J. Dalby,Nikolaj Gadegaard,Rahul S. Tare,Abhay Andar,Mathis O. Riehle,Pawel Herzyk,Chris D. W. Wilkinson,Richard O.C. Oreffo +7 more
TL;DR: The use of nanoscale disorder is demonstrated to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements, which has implications for cell therapies.
Journal ArticleDOI
Surface treatments of titanium dental implants for rapid osseointegration
TL;DR: The local release of bone stimulating or resorptive drugs in the peri-implant region may also respond to difficult clinical situations with poor bone quality and quantity, which should ultimately enhance the osseointegration process of dental implants for their immediate loading and long-term success.
Journal ArticleDOI
Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs.
Daniel Buser,Robert K. Schenk,S. G. Steinemann,Joseph P. Fiorellini,Christopher H. Fox,H. Stich +5 more
TL;DR: The extent of bone-implant interface is positively correlated with an increasing roughness of the implant surface, and hydroxylapatite (HA)-coated implants with 60-70% showed signs of resorption.
Journal ArticleDOI
Enhanced functions of osteoblasts on nanophase ceramics
TL;DR: The results of the present study provided the first evidence of enhanced long-term (on the order of days to weeks) functions of osteoblasts cultured on nanophase ceramics, and clearly represent a unique and promising class of orthopaedic/dental implant formulations with improved osseointegrative properties.