Journal ArticleDOI
The Fas Death Factor
Shigekazu Nagata,Pierre Golstein +1 more
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TLDR
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells.Abstract:
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.read more
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The thymus and negative selection
TL;DR: Evidence that negative selection can occur in the thymic medulla and affects a population of semimature HSA+ T cells is summarized and the influence of costimulatory molecules, Fas and cytokines on negative selection is discussed.
Journal ArticleDOI
The role of CTLA-4 in the regulation of T cell immune responses.
Kathy D. McCoy,G. Le Gros +1 more
TL;DR: In the present review, evidence for the proposed inhibitory role of CTLA‐4 is examined and a model suggesting a role for CTla‐4 in both early and late stages of T cell activation is presented.
Journal ArticleDOI
Fas engagement accelerates liver regeneration after partial hepatectomy.
TL;DR: It is shown that partial hepatectomy, which triggers the immediate onset of liver regeneration, protected mice against the lethal effects of Fas-specific antibodies and prevented hepatocyte apoptosis in response to Fas engagement in vivo.
Journal ArticleDOI
Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival
Wei-Ping Min,Reginald M. Gorczynski,Xuyan Huang,Michelle Kushida,Peter T. Kim,Masayuki Obataki,Ji Lei,Rakesh M. Suri,Mark S. Cattral +8 more
TL;DR: The findings suggest that DC transduced with FasL may facilitate the development of Ag-specific unresponsiveness for the prevention of organ rejection, and highlight the potential of genetically engineering DC to express other genes that affect immune responses.
Journal ArticleDOI
Shifts in the th1/th2 balance during human pregnancy correlate with apoptotic changes
TL;DR: In this paper, the authors show that both CD4+ and CD8+ T cells from peripheral blood produce less TH1 cytokines and more TH2 cytokines during normal human pregnancy and shortly after delivery than during non-pregnancy.
References
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Journal ArticleDOI
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Rie Watanabe-Fukunaga,Camilynn I. Brannan,Neal G. Copeland,Nancy A. Jenkins,Shigekazu Nagata +4 more
TL;DR: The Ipr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus.
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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
Naoto Itoh,Shin Yonehara,Ai Ishii,Minako Yonehara,Sei Ichi Mizushima,Masazumi Sameshima,Atsushi Hase,Yoshiyuki Seto,Shigekazu Nagata +8 more
TL;DR: Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells and revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain.
Journal ArticleDOI
Social controls on cell survival and cell death
TL;DR: For some mammalian cells, programmed death seems to occur by default unless suppressed by signals from other cells, so dependence on specific survival signals provides a simple way to eliminate misplaced cells, for regulating cell numbers and, perhaps, for selecting the fittest cells.
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Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
TL;DR: Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis.
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Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TL;DR: The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.