Journal ArticleDOI
The Fas Death Factor
Shigekazu Nagata,Pierre Golstein +1 more
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TLDR
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells.Abstract:
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.read more
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A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor
Elena Maestrini,Luca Tamagnone,P Longati,Ottavio Cremona,Massimo Gulisano,Silvia Bione,Filippo Tamanini,Benjamin G. Neel,Daniela Toniolo,Paolo M. Comoglio +9 more
TL;DR: In this paper, a transmembrane protein (SEX) of 1871 amino acids was identified on Xq28 encoding a highly conserved sequence, which shares significant homology with the extracellular domain of the receptors encoded by the oncogenes MET, RON, and SEA [hepatocyte growth factor (HGF) receptor family].
Journal ArticleDOI
Fas/Fas Ligand Interaction Contributes to UV-Induced Apoptosis in Human Keratinocytes
TL;DR: The data strongly suggest that the Fas system contributes to keratinocyte apoptosis in UV-irradiated human skin.
Journal ArticleDOI
Regulation mechanism of selective atresia in porcine follicles: regulation of granulosa cell apoptosis during atresia.
Noboru Manabe,Yasufumi Goto,Yasufumi Goto,Fuko Matsuda-Minehata,Naoko Inoue,Akihisa Maeda,Akihisa Maeda,Kazuhiro Sakamaki,Takashi Miyano +8 more
TL;DR: It is shown that the porcine granulosa cell is a type II apoptotic cell, which has the mitochondrion-dependent apoptosis-signaling pathway, and the cell death receptor-mediated apoptosis signaling pathway ingranulosa cells has been suggested to be as follows.
Journal ArticleDOI
Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia.
David A. Martin,Lixin Zheng,Richard M. Siegel,Baohua Huang,Galen H. Fisher,Jin Wang,Christine E. Jackson,Jennifer M. Puck,Janet K. Dale,Sharon E. Straus,Marcus E. Peter,Peter H. Krammer,Stephen W. Fesik,Michael J. Lenardo +13 more
TL;DR: It is suggested that intracytoplasmic CD95 mutations in ALPS impair apoptosis chiefly by disrupting death-domain interactions with the signaling protein FADD/MORT1.
Journal Article
The Fas-Fas ligand system and other modulators of apoptosis in the cornea.
Steven E. Wilson,Qian Li,Jian Weng,Patricia A. Barry-Lane,James V. Jester,Qianwa Liang,Robert J. Wordinger +6 more
TL;DR: The Fas system (Fas and Fas ligand) modulators and final common pathway mediators of apoptosis are expressed in corneal cells and the Fas-Fas ligand system is expressed in the cornea and could have important functions in normal cornea physiology and in the pathophysiology of cornea disease, including modulation of keratocyte apoptosis after epithelial injury.
References
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Journal ArticleDOI
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Rie Watanabe-Fukunaga,Camilynn I. Brannan,Neal G. Copeland,Nancy A. Jenkins,Shigekazu Nagata +4 more
TL;DR: The Ipr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus.
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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
Naoto Itoh,Shin Yonehara,Ai Ishii,Minako Yonehara,Sei Ichi Mizushima,Masazumi Sameshima,Atsushi Hase,Yoshiyuki Seto,Shigekazu Nagata +8 more
TL;DR: Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells and revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain.
Journal ArticleDOI
Social controls on cell survival and cell death
TL;DR: For some mammalian cells, programmed death seems to occur by default unless suppressed by signals from other cells, so dependence on specific survival signals provides a simple way to eliminate misplaced cells, for regulating cell numbers and, perhaps, for selecting the fittest cells.
Journal ArticleDOI
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
TL;DR: Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis.
Journal ArticleDOI
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.
TL;DR: The CD8+ effector cells raised in the CD4 subset- deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.