Open AccessJournal Article
[The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia].
Birkmayer W,Hornykiewicz O +1 more
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This article is published in Wiener Klinische Wochenschrift.The article was published on 1961-11-10 and is currently open access. It has received 459 citations till now.read more
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Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
TL;DR: D dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms are discussed.
Journal ArticleDOI
100 years of Lewy pathology
TL;DR: The relevance of Lewy's discovery 100 years ago for the current understanding of PD and related disorders is reviewed.
Journal ArticleDOI
Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease
Peter Redgrave,Manuel Rodriguez,Manuel Rodriguez,Yoland Smith,Yoland Smith,Maria C. Rodriguez-Oroz,Maria C. Rodriguez-Oroz,Stéphane Lehéricy,Hagai Bergman,Yves Agid,Mahlon R. DeLong,Jose A. Obeso,Jose A. Obeso +12 more
TL;DR: In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour, and patients may be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum.
Journal ArticleDOI
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
Justine D. Miller,Yosif Ganat,Sarah Kishinevsky,Robert L. Bowman,Becky Liu,Edmund Y. Tu,Pankaj Mandal,Pankaj Mandal,Elsa Vera,Jae-Won Shim,Sonja Kriks,Tony Taldone,Noemi Fusaki,Mark J. Tomishima,Dimitri Krainc,Teresa A. Milner,Teresa A. Milner,Derrick J. Rossi,Derrick J. Rossi,Lorenz Studer +19 more
TL;DR: It is suggested that progerin-induced aging can be used to reveal late-onset age-related disease features in hiPSC-based disease models.
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[Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system].
H. Ehringer,Oleh Hornykiewicz +1 more