Journal ArticleDOI
The L-arginine : nitric oxide pathway is the major source of plasma nitrite in fasted humans
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TLDR
The results indicate that the measurement of these compounds in plasma is a valid indicator of NO generation in fasted human volunteers and thus defines the quantitative relationship between the L-arginine:nitric oxide (NO) pathway and the formation of these oxides of nitrogen.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1995-04-17. It has received 320 citations till now. The article focuses on the topics: Nitrite & Nitrate.read more
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Journal ArticleDOI
Methods to detect nitric oxide and its metabolites in biological samples
TL;DR: The methods described in this review are not an exhaustive or comprehensive discussion of all methods available for the detection of NO but rather a description of the most commonly used and practical methods which allow accurate and sensitive quantification of NO products/metabolites in multiple biological matrices under normal physiological conditions.
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Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research.
TL;DR: The present article gives an overview of the currently available assays of nitrite and nitrate in biological fluids based on the Griess reaction, the most frequently used analytical approach to quantitate the major metabolites of NO, i.e. nitriteand nitrate, in a variety of biological fluids, notably blood and urine.
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Nitric oxide metabolism and breakdown
TL;DR: Increasing knowledge on the complex metabolism of NO in vivo will lead to the development of new therapeutic strategies to enhance bioactivity of NO via modulation of its metabolism.
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Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
Petra Kleinbongard,Andre Dejam,Thomas Lauer,Tienush Rassaf,Tienush Rassaf,A.W. Schindler,Olaf Picker,Thomas Scheeren,Axel Gödecke,Jürgen Schrader,Rainer Schulz,Gerd Heusch,Günter A. Schaub,Nathan S. Bryan,Martin Feelisch,Malte Kelm +15 more
TL;DR: Evidence is provided for a uniform constitutive vascular NOS-activity across mammalian species by determining plasma nitrite concentration to be in a nanomolar range in a variety of species.
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Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
Thomas Lauer,Michael Preik,Tienush Rassaf,Bodo E. Strauer,Andreas Deussen,Martin Feelisch,Malte Kelm +6 more
TL;DR: The results contradict the current paradigm that plasma NO3− and/or total NOx are generally useful markers of endogenous NO production and demonstrate that only NO2− reflects acute changes in regional eNOS activity and physiological levels of nitrite are vasodilator-inactive.