The Network Mechanism of the Central Circadian Pacemaker of the SCN: Do AVP Neurons Play a More Critical Role Than Expected?
Reads0
Chats0
TLDR
A brief overview of the current knowledge concerning the differential roles of multiple neuropeptide-expressing neurons in the SCN is provided, especially focusing on the emerging roles of arginine vasopressin-producing neurons uncovered by recent studies utilizing neuron type-specific genetic manipulations in mice.Abstract:
The suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker in mammals and entrains to the environmental light/dark cycle. It is composed of multiple types of GABAergic neurons, and interneuronal communications among these neurons are essential for the circadian pacemaking of the SCN. However, the mechanisms underlying the SCN neuronal network remain unknown. This review will provide a brief overview of the current knowledge concerning the differential roles of multiple neuropeptides and neuropeptide-expressing neurons in the SCN, especially focusing on the emerging roles of arginine vasopressin-producing neurons uncovered by recent studies utilizing neuron type-specific genetic manipulations in mice.read more
Citations
More filters
Journal ArticleDOI
New Insights Into the Circadian Rhythm and Its Related Diseases
TL;DR: This review summarized the synchronizers and the synchronization methods used in experimental research, and introduced CR monitoring and detection methods, and evaluated conventional CR databases and analyzed experiments that characterized the underlying causes of CR disorder.
Journal ArticleDOI
The Glymphatic System: A Novel Component of Fundamental Neurobiology.
TL;DR: In this article, the authors provide evidence that astrocytes and blood vessels determine the shape of the perivascular space, ultimately controlling the movement of periarterial fluid, which has the potential to alter local as well as global transport of signaling molecules and metabolites.
Journal ArticleDOI
Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects.
Dinushan Nesan,Dinushan Nesan,Kira M. Feighan,Kira M. Feighan,Michael C. Antle,Deborah M. Kurrasch,Deborah M. Kurrasch +6 more
TL;DR: In this article, fetal exposure to the endocrine disruptor found in common plastics, bisphenol A (BPA), causes lasting effects on adult animal behaviors, such as sleep and stress.
Journal ArticleDOI
Pharmacological Manipulation of the Circadian Clock: A Possible Approach to the Management of Bipolar Disorder
TL;DR: It is expected this work will serve as a roadmap to facilitate the development of compounds acting on the circadian clock for the treatment of BD and evaluate some of the candidate clock pathways and systems that could serve as potential targets for novel mood stabilizers.
Journal ArticleDOI
Circadian Clocks of the Kidney: Function, Mechanism, and Regulation.
TL;DR: This review summarizes what is currently known regarding the function, mechanism, and regulation of kidney clocks and the effect of extra-renal physiological processes on kidney function.
References
More filters
Journal ArticleDOI
Coordination of circadian timing in mammals
TL;DR: Circadian rhythms are generated by one of the most ubiquitous and well-studied timing systems and are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world.
Journal ArticleDOI
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
TL;DR: The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals, and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus.
Journal ArticleDOI
Transcriptional architecture of the mammalian circadian clock
TL;DR: Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling.
Journal ArticleDOI
Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals
Maureen K. Bunger,Lisa D. Wilsbacher,Susan M. Moran,Cynthia Clendenin,Laurel A. Radcliffe,John B. Hogenesch,M. Celeste Simon,Joseph S. Takahashi,Christopher A. Bradfield +8 more
TL;DR: Analysis of Period gene expression in the suprachiasmatic nucleus (SCN) indicates that these behavioral phenotypes arise from loss of circadian function at the molecular level, and provides genetic evidence that MOP3 is the bona fide heterodimeric partner of mCLOCK.
Journal ArticleDOI
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
TL;DR: The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances their precision.