The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center.
David A. Johnson,James Travis +1 more
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This article is published in Journal of Biological Chemistry.The article was published on 1979-05-25 and is currently open access. It has received 467 citations till now. The article focuses on the topics: Reactive center & Methionine.read more
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Production of Large Amounts of Hydrogen Peroxide by Human Tumor Cells
Ted P. Szatrowski,Carl Nathan +1 more
TL;DR: Constitutive generation of large amounts of reactive oxygen intermediates, if it occurs in vivo, might contribute to the ability of some tumors to mutate, inhibit antiproteases, injure local tissues, and therefore promote tumor heterogeneity, invasion, and metastasis.
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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease
Warren J. Strittmatter,Karl H. Weisgraber,David Huang,Li Ming Dong,Guy S. Salvesen,Margaret A. Pericak-Vance,Donald E. Schmechel,Ann M. Saunders,Dmitry Goldgaber,Allen D. Roses +9 more
TL;DR: Differences in the two isoforms in complexing with the beta/A4 peptide may be involved in the pathogenesis of the intra- and extracellular lesions of Alzheimer disease.
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Neutrophil Function: From Mechanisms to Disease
TL;DR: A survey of basic neutrophil biology, with an emphasis on examples that highlight the function of neutrophils not only as professional killers, but also as instructors of the immune system in the context of infection and inflammatory disease.
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Persistent oxidative stress in cancer
TL;DR: It is suggested that the concept of ‘persistent oxidative stress in cancer’ may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto‐oncogenes, genomic instability, chemotherapy‐resistance, invasion and metastasis.
References
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A spectrophotometric determination of trypsin and chymotrypsin
George W. Schwert,Yasuo Takenaka +1 more
TL;DR: A sensitive spectrophotometric assay for trypsin and chymotrypsin using synthetic substrates has been described.
Journal ArticleDOI
The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency
Carl-Bertil Laurell,S. Eriksson +1 more
TL;DR: In this paper, the Electrophoretic α, 1-Globulin Pattern of Serum in α; 1-Antitrypsin Deficiency; and 1-Girdhar et al.
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The synthesis and analytical use of a highly sensitive and convenient substrate of elastase.
TL;DR: The synthesis and analytical use of succinyl-( l -alanine) 3 - p -nitroanilide, a new elastase substrate that is virtually not attacked by trypsin or chymotrypsin and does not undergo appreciable spontaneous hydrolysis is described.
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High recovery of tryptophan from acid hydrolysates of proteins
TL;DR: Moderate concentrations of thioglycolic acid largely prevented the destruction of tryptophan during acid hydrolysis of proteins.
Journal ArticleDOI
Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.
TL;DR: Two tetrapeptide 4-nitroanilide substrates related to the reactive site of the plasma (~1’ protease inhibitor) were studied and indicate that oxidation of the PI Met of YePI is capable to destroying its reactivity toward most serine proteases.
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Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin.
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