Open AccessJournal Article
The oxidative stress hypothesis in Alzheimer's disease.
Manuela Padurariu,Alin Ciobica,Radu Lefter,Ionela Lacramioara Serban,Cipriana Stefanescu,Roxana Chirita +5 more
TLDR
There is a need for further research regarding antioxidant therapy in very early stages of dementia because studies have failed to prove a clear benefit for antioxidant treatment in dementia.Abstract:
Oxidative stress may be involved in many somatic and psychiatric pathological states including dementia. The hypothesis of oxidative stress involvement in dementia is supported by much scientific data through biochemical, genetic and molecular studies. Thus, there are many reports of an increased level of the markers for oxidative damage, alterations in the specific activity of the antioxidant system, mutations in specific genes, mitochondrial disturbances and also several connections between oxidative stress and amyloid plaques. Despite these evidence and clinical approaches in using antioxidant therapy in dementia treatment, studies have failed to prove a clear benefit for antioxidant treatment in dementia. Hence, there is a need for further research regarding antioxidant therapy in very early stages of dementia.read more
Citations
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Oxidative stress and the amyloid beta peptide in Alzheimer's disease.
Clémence Cheignon,M. Tomas,M. Tomas,Dominique Bonnefont-Rousselot,Peter Faller,Christelle Hureau,Christelle Hureau,Fabrice Collin,Fabrice Collin +8 more
TL;DR: This review highlights the existing link between oxidative stress and AD, and the consequences towards the Aβ peptide and surrounding molecules in terms of oxidative damage, along with the implication of metal ions in AD.
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Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
Anu Rahal,Amit Kumar,Vivek Singh,Brijesh Yadav,Ruchi Tiwari,Sandip Chakraborty,Kuldeep Dhama +6 more
TL;DR: The importance of oxidative stress in the body growth and development as well as proteomic and genomic evidences of its relationship with disease development, incidence of malignancies and autoimmune disorders, increased susceptibility to bacterial, viral, and parasitic diseases are discussed.
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
Journal ArticleDOI
Role of oxidative stress in Alzheimer's disease (Review)
TL;DR: The current review examined the role of oxidative stress in AD, a process referring to an imbalance between antioxidants and oxidants in favour of oxidants that can occur as a result of increased free radicals or a decrease in antioxidant defense.
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Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease
TL;DR: This review presents evidence, gathered over the last decade, concerning a variety of pathogenic proteins, their important signaling pathways and pathogenic mechanisms associated with oxidative stress in Parkinson's disease and Alzheimer's disease, and emphasizes antioxidative options.
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TL;DR: These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’.
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TL;DR: Recognition of upstream and downstream antioxidant therapy to oxidative stress has been proved an effective tool in alteration of any neuronal damage as well as free radical scavenging.
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A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress
TL;DR: The physiological origin of MDA is described, its toxicity is highlighted, and the most common methods of detection are insufficiently sensitive and disturbed by interference coming from related species or overestimation derived from stressing analysis conditions.