The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.
Naveenan Navaratnam,John R. Morrison,Shoumo Bhattacharya,Dipti Patel,T. Funahashi,F. Giannoni,Ba-Bie Teng,Nicholas O. Davidson,James Scott +8 more
TLDR
It is concluded that p27 is the catalytic subunit of the apolipoprotein B mRNA editing enzyme and is a zinc-containing cytidine deaminase.About:
This article is published in Journal of Biological Chemistry.The article was published on 1993-10-05 and is currently open access. It has received 278 citations till now. The article focuses on the topics: Cytidine deaminase activity & APOBEC-1 Deaminase.read more
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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
Patrick Revy,Taro Muto,Yves Levy,Frederic Geissmann,Alessandro Plebani,Ozden Sanal,Nadia Catalan,Monique Forveille,Dufourcq-Lagelouse R,Andrew R. Gennery,Ilhan Tezcan,Fügen Ersoy,Hülya Kayserili,Alberto G. Ugazio,Nicole Brousse,Masamichi Muramatsu,Luigi D. Notarangelo,Kazuo Kinoshita,Tasuku Honjo,Alain Fischer,Anne Durandy +20 more
TL;DR: The phenotype observed in HIGM2 patients (and in AID-/- mice) demonstrates the absolute requirement for AID in several crucial steps of B cell terminal differentiation necessary for efficient antibody responses.
Journal ArticleDOI
Recent Advances in Zinc Enzymology
TL;DR: Zinc enzymology is, compared to some other current areas of metallobiochemistry, a maturing field, but in addition to further developments of structure-function relationships it has also provided a number of surprising new results and ideas in the last few years.
Journal ArticleDOI
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
Masamichi Muramatsu,V.S. Sankaranand,Shrikant Anant,Manabu Sugai,Kazuo Kinoshita,Nicholas O. Davidson,Tasuku Honjo +6 more
TL;DR: Findings suggest that AID is a new member of the RNA-editing deaminase family and may play a role in genetic events in the germinal center B cell.
Journal ArticleDOI
Active DNA demethylation: many roads lead to Rome
Susan C. Wu,Yi Zhang +1 more
TL;DR: Insight into how DNA methylation is dynamically regulated will broaden the understanding of epigenetic regulation and have great implications in somatic cell reprogramming and regenerative medicine.
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An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.
Adam Jarmuz,Ann Chester,J.D. Bayliss,Jane Gisbourne,Ian Dunham,James Scott,Naveenan Navaratnam +6 more
TL;DR: Tissue-specific expression of these genes in a variety of cell lines, along with other evidence, suggests a role for these enzymes in growth or cell cycle control, and similarity in amino acid sequence with APOBEC1, conserved intron/exon organization, tissue- specific expression, homodimerization, and zinc and RNA binding similar to APOB EC1 is concluded.
References
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.
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A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
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A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine.
TL;DR: It is suggested that a co- or posttranscriptional C----U change may result in the production of apo-B48, which represents the amino-terminal 2152 amino acids of api-B100, which is the first example of tissue-specific modification of a single mRNA nucleotide resulting in two different proteins from the same primary transcript.
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Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon.
San Hwan Chen,Geetha Habib,Chao Yuh Yang,Zi Wei Gu,Bo rong Lee,Shi Ai Weng,Steven R. Silberman,Sheng Jian Cai,J. P. Deslypere,Maryvonne Rosseneu,Antonio M. Gotto,Wen-Hsiung Li,Lawrence Chan +12 more
TL;DR: Data indicate that approximately 85% of the intestinal mRNAs terminate within approximately 0.1 to 1.0 kilobase downstream from the stop codon, which might have implications for cryptic polyadenylation signal recognition and RNA processing.
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An unwinding activity that covalently modifies its double-stranded RNA substrate.
Brenda L. Bass,Harold Weintraub +1 more
TL;DR: It is demonstrated that during the reaction many, but not all, of the adenosine residues are converted to inosine residues, and it is proposed that the covalent modification is responsible for the irreversible change in base pairing properties.