The plasma lecithin:cholesterol acyltransferase reaction
TLDR
Several indications exist that the acyltransferase reaction is the major source of plasma esterified cholesterol in man, and one possibility is that it plays a role in the transport of cholesterol from peripheral tissues to the liver.About:
This article is published in Journal of Lipid Research.The article was published on 1968-03-01 and is currently open access. It has received 2336 citations till now. The article focuses on the topics: Lecithin cholesterol acyltransferase deficiency & Reverse cholesterol transport.read more
Citations
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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
TL;DR: Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body.
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Plasma-high-density-lipoprotein concentration and development of ischæmic heart-disease
G.J Miller,N.E Miller +1 more
TL;DR: The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins, and it is proposed that a reduction of plasma-H.H.L.D., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease, by impairing the clearance of cholesterol from the arterial wall.
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Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
Amit Khera,Marina Cuchel,Margarita de la Llera-Moya,Amrith Rodrigues,Megan F. Burke,Kashif Jafri,Benjamin French,Julie A. Phillips,Megan L. Mucksavage,Robert L. Wilensky,Emile R. Mohler,George H. Rothblat,Daniel J. Rader +12 more
TL;DR: Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima-media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level.
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High-Density Lipoprotein — The Clinical Implications of Recent Studies
David Gordon,Basil M. Rifkind +1 more
TL;DR: A large number of animal studies have shown an association between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease, and the possible protective role of HDL in athero...
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Molecular physiology of reverse cholesterol transport.
TL;DR: The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated, and RCT can now be understood in molecular terms.
References
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The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
The mechanism of the plasma cholesterol esterification reaction : Plasma fatty acid transferase.
TL;DR: The present findings support the hypothesis that cholesterol esters are formed in plasma by the action of a fatty acid transferase, that the majority of the transesterified fatty acids originate from teh C-2 position of the plasma lecithin, and that the reaction may be of considerable importance in vivo.
Journal ArticleDOI
Some properties of a cholesterol esterifying enzyme in human plasma.
John A. Glomset,John Wright +1 more
TL;DR: A method for the radioassay of plasma cholesterol esterifying activity has been developed and the reaction is irreversibly inactivated by urea, while the inhibition by sodium taurocholate is reversible.
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The formation of cholesterol esters with rat liver enzymes.
TL;DR: Experiments dealing with the formation of long chain fatty acid esters of cholesterol with rat liver preparations found that the bulk of hydrolytic enzyme activity is present in the soluble fraction of the liver homogenate.
Journal ArticleDOI
Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat.
TL;DR: The highest rate of cholesterogenesis in the cholesterol-fed or fasted rat is found in the gastrointestinal tract, and this conclusion applies to synthesis of cholesterol and of five other digitonin-precipitable tissue sterols.
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Plasma-high-density-lipoprotein concentration and development of ischæmic heart-disease
G.J Miller,N.E Miller +1 more