The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer
Carole Fakhry,William H. Westra,Steven J. Wang,Annemieke van Zante,Yuehan Zhang,Eleni M. Rettig,Linda X. Yin,William R. Ryan,Patrick K. Ha,Alicia Wentz,Wayne M. Koch,Jeremy D. Richmon,David W. Eisele,Gypsyamber D'Souza +13 more
TLDR
Survival differences were explored by the tumor HPV status among patients with OPSCCs by sex and race and patients with nonoropharyngeal (non‐OP) head and neck squamous cell cancers (HNSCCs).Abstract:
BACKGROUND
Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs).
METHODS
This retrospective, multi-institution study included OPSCCs and non-OP HNSCCs of the oral cavity, larynx, and nasopharynx diagnosed from 1995 to 2012. Race/ethnicity was categorized as white non-Hispanic, black non-Hispanic, Asian non-Hispanic, and Hispanic of any race. Tumors were centrally tested for p16 overexpression and the presence of HPV by HPV16 DNA and high-risk HPV E6/E7 messenger RNA in situ hybridization. Kaplan-Meier and Cox proportional hazards models were used to evaluate overall survival (OS).
RESULTS
The study population included 239 patients with OPSCC and 621 patients with non-OP HNSCC with a median follow-up time of 3.5 years. After adjustments for the tumor HPV status, age, current tobacco use, and stage, the risk of death was lower for women versus men with OPSCC (adjusted hazard ratio, 0.55; P = .04). The results were similar with p16. In contrast, for non-OP HNSCCs, HPV positivity, p16 positivity, and sex were not associated with OS.
CONCLUSIONS
For OPSCC, there are differences in survival by sex, even after the tumor HPV status has been taken into account. For non-OP HNSCC, the HPV status and the p16 status are not of prognostic significance. Cancer 2017;123:1566–1575. © 2017 American Cancer Society.read more
Citations
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Prognostic impact of leukocyte counts before and during radiotherapy for oropharyngeal cancer.
Garrett Jensen,Pierre Blanchard,Pierre Blanchard,G. Brandon Gunn,Adam S. Garden,C. David Fuller,Erich M. Sturgis,Maura L. Gillison,Jack Phan,William H. Morrison,David I. Rosenthal,Steven J. Frank +11 more
TL;DR: The prognostic value of pretreatment blood counts is investigated and the impact of treatment modality (IMPT and IMRT) on nadir neutrophil & lymphocyte levels during radiotherapy is examined.
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Survival Outcomes in Human Papillomavirus-Associated Nonoropharyngeal Squamous Cell Carcinomas: A Systematic Review and Meta-analysis.
Axel Sahovaler,Axel Sahovaler,Min Hui Kim,Adrian Mendez,David A. Palma,Kevin Fung,John Yoo,Anthony C. Nichols,S. Danielle MacNeil +8 more
TL;DR: HPV was associated with improved OS in laryngeal and hypopharyngeAl locations but not in the oral cavity and the nasopharynx, and whether HPV status should be incorporated in prognostication of patients with these cancers is investigated.
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Racial disparities and human papillomavirus status in oropharyngeal cancer: A systematic review and meta-analysis.
TL;DR: This study used a meta‐analysis to quantify the degree to which the racial disparity in overall survival for black versus white Americans with oropharyngeal squamous cell carcinoma persists after adjusting for human papillomavirus (HPV) status.
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Treatment modality and outcomes in larynx cancer patients: A sex-based evaluation.
TL;DR: To evaluate the differences in treatment modality and outcomes between male and female patients with laryngeal squamous cell carcinoma in the United States, a large number of patients are male and the prognosis is poor.
References
More filters
Journal ArticleDOI
Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States
Anil K. Chaturvedi,Eric A. Engels,Ruth M. Pfeiffer,Brenda Y. Hernandez,Weihong Xiao,Esther Kim,Bo Jiang,Marc T. Goodman,Maria Sibug-Saber,Wendy Cozen,Lihua Liu,Charles F. Lynch,Nicolas Wentzensen,Richard C.K. Jordan,Sean F. Altekruse,William F. Anderson,Philip S. Rosenberg,Maura L. Gillison +17 more
TL;DR: In this article, the prevalence of human papillomavirus (HPV) infection in oropharyngeal cancer was determined for all 271 oropharygeal cancers (1984-2004) collected by the three population-based cancer registries in the Surveillance, Epidemiology, and End Results (SEER) Residual Tissue Repositories Program.
Journal ArticleDOI
Improved Survival of Patients With Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial
Carole Fakhry,William H. Westra,S. Li,Anthony J. Cmelak,John A. Ridge,Harlan A. Pinto,Arlene A. Forastiere,Maura L. Gillison +7 more
TL;DR: For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival and, after adjustment for age, tumor stage, and ECOG performance status, lower risks of progression and death are found.
Journal ArticleDOI
Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers
Anil K. Chaturvedi,William F. Anderson,Joannie Lortet-Tieulent,Maria Paula Curado,Jacques Ferlay,Silvia Franceschi,Philip S. Rosenberg,Freddie Bray,Maura L. Gillison +8 more
TL;DR: OPC incidence significantly increased during 1983 to 2002 predominantly in developed countries and at younger ages, underscore a potential role for HPV infection on increasing OPC incidence, particularly among men.
Journal ArticleDOI
Epidemiology of Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma
TL;DR: Recent data are reviewed to provide insight into several topics, including incidence trends and projections for HPV-positive HNC; the worldwide HPV-attributable fraction; sex disparities in cancer risk; the epidemiology of oral HPV infection; the latency period between infection and cancer; the potential impact of prophylactic HPV vaccination; and prospects for secondary prevention.
Journal ArticleDOI
A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen.
Serge J. Smeets,Albertus T. Hesselink,Ernst-Jan M. Speel,Annick Haesevoets,Peter J.F. Snijders,Michael Pawlita,Chris J.L.M. Meijer,Boudewijn J.M. Braakhuis,C. René Leemans,Ruud H. Brakenhoff +9 more
TL;DR: It is shown that clinically meaningful viral HPV infections can be more reliably measured in FFPE H NSCC samples in a standard and high throughput manner, paving the way for prognostic and experimental vaccination studies, regarding not only HNSCC, but possibly also cancer types with HPV involvement in subgroups such as penile and anal cancer.
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