The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer
Carole Fakhry,William H. Westra,Steven J. Wang,Annemieke van Zante,Yuehan Zhang,Eleni M. Rettig,Linda X. Yin,William R. Ryan,Patrick K. Ha,Alicia Wentz,Wayne M. Koch,Jeremy D. Richmon,David W. Eisele,Gypsyamber D'Souza +13 more
TLDR
Survival differences were explored by the tumor HPV status among patients with OPSCCs by sex and race and patients with nonoropharyngeal (non‐OP) head and neck squamous cell cancers (HNSCCs).Abstract:
BACKGROUND
Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs).
METHODS
This retrospective, multi-institution study included OPSCCs and non-OP HNSCCs of the oral cavity, larynx, and nasopharynx diagnosed from 1995 to 2012. Race/ethnicity was categorized as white non-Hispanic, black non-Hispanic, Asian non-Hispanic, and Hispanic of any race. Tumors were centrally tested for p16 overexpression and the presence of HPV by HPV16 DNA and high-risk HPV E6/E7 messenger RNA in situ hybridization. Kaplan-Meier and Cox proportional hazards models were used to evaluate overall survival (OS).
RESULTS
The study population included 239 patients with OPSCC and 621 patients with non-OP HNSCC with a median follow-up time of 3.5 years. After adjustments for the tumor HPV status, age, current tobacco use, and stage, the risk of death was lower for women versus men with OPSCC (adjusted hazard ratio, 0.55; P = .04). The results were similar with p16. In contrast, for non-OP HNSCCs, HPV positivity, p16 positivity, and sex were not associated with OS.
CONCLUSIONS
For OPSCC, there are differences in survival by sex, even after the tumor HPV status has been taken into account. For non-OP HNSCC, the HPV status and the p16 status are not of prognostic significance. Cancer 2017;123:1566–1575. © 2017 American Cancer Society.read more
Citations
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Journal ArticleDOI
Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy.
Madison Canning,Gang Guo,Miao Yu,Calvin Wint Maung Myint,Michael W. Groves,James Kenneth Byrd,Yan Cui +6 more
TL;DR: There is an urgent and unmet need for the identification of specific molecular signatures that better predict the clinical outcomes and markers that serve as better therapeutic targets for HNSCC patients with recurrent disease.
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Human Papillomavirus Testing in Head and Neck Carcinomas: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists Guideline
Carole Fakhry,Christina Lacchetti,Lisa M. Rooper,Richard C.K. Jordan,Danny Rischin,Erich M. Sturgis,Diana Bell,Mark W. Lingen,Seema Harichand-Herdt,John Thibo,Jose P. Zevallos,Bayardo Perez-Ordonez +11 more
TL;DR: The ASCO Expert Panel determined that the recommendations from the HPV Testing in Head and Neck Carcinomas guideline, published in 2018, are clear, thorough, and based upon the most relevant scientific evidence.
Journal ArticleDOI
Human papillomavirus as a driver of head and neck cancers.
TL;DR: This review summarises the current understanding of HPV in these cancers, specifically detailing HPV infection in head and neck cancers within different racial/ethnic subpopulations, and the differences in various aspects of these diseases between women and men.
Journal ArticleDOI
Association of Human Papillomavirus Status at Head and Neck Carcinoma Subsites With Overall Survival.
Hong Li,Sina J. Torabi,Wendell G. Yarbrough,Saral Mehra,Saral Mehra,Heather A. Osborn,Heather A. Osborn,Benjamin L. Judson,Benjamin L. Judson +8 more
TL;DR: Human papillomavirus positivity was associated with improved survival in 4 subsites (oropharynx, hypopharynX, oral cavity, and larynx), and the largest survival difference was noted in the oropharynx and hypopharyx subsites.
Journal ArticleDOI
Increasing prevalence of human papillomavirus-positive oropharyngeal cancers among older adults.
Melina J. Windon,Gypsyamber D'Souza,Eleni M. Rettig,William H. Westra,Annemieke van Zante,Steven J. Wang,William R. Ryan,Wojciech K. Mydlarz,Patrick K. Ha,Brett A. Miles,Wayne M. Koch,Christine G. Gourin,David W. Eisele,Carole Fakhry +13 more
TL;DR: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults and it is unknown whether these trends can be explained by human papillomavirus (HPV) and whether HPV‐related tumors remain associated with an improved prognosis among older patients.
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Kathleen Settle,Marshall R. Posner,Lisa M. Schumaker,Ming Tan,Mohan Suntharalingam,Olga Goloubeva,Scott E. Strome,Robert I. Haddad,Shital S. Patel,Earl V. Cambell,Nicholas J. Sarlis,Jochen H. Lorch,Kevin J. Cullen +12 more
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