Journal ArticleDOI
The resolution of inflammation.
TLDR
Five of the speakers from the 2012 Nature Reviews Immunology conference are asked to share their thoughts on this emerging field of inflammation management.Abstract:
In 2012, Nature Reviews Immunology organized a conference that brought together scientists and clinicians from both academia and industry to discuss one of the most pressing questions in medicine--how do we turn off rampant, undesirable inflammation? There is a growing appreciation that, similarly to the initiation of inflammation, the resolution of inflammation is an intricate and active process. Can we therefore harness the mediators involved in resolution responses to treat patients with chronic inflammatory or autoimmune diseases? Here, we ask five of the speakers from the conference to share their thoughts on this emerging field.read more
Citations
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Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy
Maria Reig,Zoe Mariño,Christie Perelló,Mercedes Iñarrairaegui,Andrea Ribeiro,Sabela Lens,Alba Díaz,Ramón Vilana,Anna Darnell,Maria Varela,Bruno Sangro,Jose Luis Calleja,Xavier Forns,Jordi Bruix +13 more
TL;DR: The data show an unexpected high rate and pattern of tumor recurrence coinciding with HCV clearance and, although based in a very small cohort of patients, should be taken as a note of caution and prime a large scale assessment that exceeds the individual investigators capacity.
Journal ArticleDOI
Neutrophil migration in infection and wound repair: going forward in reverse.
TL;DR: The different cues within tissues that mediate neutrophil forward and reverse migration in response to injury or infection are discussed and the implications of these mechanisms to human disease are discussed.
Journal ArticleDOI
Resolution of inflammation: a new therapeutic frontier.
TL;DR: The state of the art in the biology of resolution of inflammation is discussed, highlighting the opportunities and challenges for translational research in this field.
Journal ArticleDOI
Diverse macrophage populations mediate acute lung inflammation and resolution
TL;DR: Experimental animal models of acute lung injury (ALI) reproduce key components of the injury and resolution phases of human ARDS and provide a methodology to explore mechanisms and potential new therapies and highlight human studies that relate to the diverse role of macrophages in initiation and resolution of ALI and ARDS.
Journal ArticleDOI
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
TL;DR: While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition.
References
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Journal ArticleDOI
Resolution of inflammation: the beginning programs the end.
Charles N. Serhan,John Savill +1 more
TL;DR: Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.
Journal ArticleDOI
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.
Charles N. Serhan,Song Hong,Karsten Gronert,Sean P. Colgan,Pallavi R. Devchand,Gudrun E. Mirick,Rose-Laure Moussignac +6 more
TL;DR: It is reported that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and docosahexaenoic acid produce a novel family of bioactive 17R-hydroxy-containing di- and tri-Hydroxy-docosanoids termed resolvins.
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Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Jeremy S. Duffield,Stuart J. Forbes,Christothea M. Constandinou,Spike Clay,Marina Partolina,Srilatha Vuthoori,Shengji Wu,Richard A. Lang,John P. Iredale +8 more
TL;DR: These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophage play critical roles in both the injury and recovery phases of inflammatory scarring.
Journal ArticleDOI
Inducible cyclooxygenase may have anti-inflammatory properties.
Derek W. Gilroy,Paul Colville-Nash,Dean Willis,J. Chivers,Mark J. Paul-Clark,Derek A. Willoughby +5 more
TL;DR: COX 2 may be pro-inflammatory during the early phase of a carrageenin-induced pleurisy, but may aid resolution at the later, mononuclear cell-dominated phase by generating an alternative set of anti-inflammatory prostaglandins.
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Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing
TL;DR: It is reported that inflammatory exudates from mice treated with ω-3 polyunsaturated fatty acid and aspirin (ASA) generate a novel array of bioactive lipid signals, which provides a novel mechanism for the therapeutic benefits ofπ-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases.