The Right Ventricle Under Pressure: Cellular and Molecular Mechanisms of Right-Heart Failure in Pulmonary Hypertension
TLDR
This overview identifies the gaps in the understanding of RV failure and attempts to fill them, when possible, and aims to encourage the pulmonary hypertension research community to direct some of their attention to the RV, in parallel to their focus on the pulmonary vasculature.About:
This article is published in Chest.The article was published on 2009-03-01 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Pressure overload & Afterload.read more
Citations
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Journal ArticleDOI
Right Heart Adaptation to Pulmonary Arterial Hypertension: Physiology and Pathobiology
Anton Vonk-Noordegraaf,Francois Haddad,Kelly Chin,Paul R. Forfia,Steven M. Kawut,Joost Lumens,Robert Naeije,John H. Newman,Ronald J. Oudiz,Steve Provencher,Adam Torbicki,Norbert F. Voelkel,Norbert F. Voelkel,Paul M. Hassoun +13 more
TL;DR: The authors highlight differences between right and left heart failure and outline key areas of future investigation in right heart pathobiology in PAH.
Journal ArticleDOI
Mechanisms of disease: pulmonary arterial hypertension
TL;DR: Perturbations of a number of molecular mechanisms have been described, including pathways involving growth factors, cytokines, metabolic signaling, elastases, and proteases, that may underlie the pathogenesis of the disease.
Journal ArticleDOI
Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure
Harm Jan Bogaard,Ramesh Natarajan,Scott C. Henderson,Carlin S. Long,Donatas Kraskauskas,Lisa Smithson,Ramzi A Ockaili,Joe M. McCord,Norbert F. Voelkel +8 more
TL;DR: In this article, a mechanical animal model of chronic progressive pulmonary arterial pressure overload (pulmonary artery banding, not associated with structural alterations of the lung circulation) was compared with an established model of angioproliferative pulmonary hypertension associated with fatal RV failure.
Journal ArticleDOI
The monocrotaline model of pulmonary hypertension in perspective
Jose Gomez-Arroyo,Laszlo Farkas,Aysar Alhussaini,Daniela Farkas,Donatas Kraskauskas,Norbert F. Voelkel,Harm Jan Bogaard +6 more
TL;DR: Although the monocrotaline rat model of PAH has contributed to a better understanding of vascular remodeling in pulmonary hypertension, the validity of this model as a preclinically relevant model of severe plexogenic PAH is questioned.
Journal ArticleDOI
Anatomy, Function, and Dysfunction of the Right Ventricle: JACC State-of-the-Art Review
Javier Sanz,Javier Sanz,Damián Sánchez-Quintana,Eduardo Bossone,Harm Jan Bogaard,Robert Naeije +5 more
TL;DR: Current knowledge of the right ventricle (RV) anatomic, structural, metabolic,functional, functional, and hemodynamic characteristics in both health and disease is summarized.
References
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The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
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Bone marrow cells regenerate infarcted myocardium
Donald Orlic,Jan Kajstura,Stefano Chimenti,Igor Jakoniuk,Stacie M. Anderson,Baosheng Li,James Pickel,Ronald D.G. McKay,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +11 more
TL;DR: It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
Journal ArticleDOI
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
Journal ArticleDOI
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
Journal ArticleDOI
Survival in Patients with Primary Pulmonary Hypertension: Results from a National Prospective Registry
Gilbert E. D'Alonzo,Robyn J. Barst,Stephen M. Ayres,Edward H. Bergofsky,Bruce H. Brundage,Katherine M. Detre,Alfred P. Fishman,Roberta M. Goldring,Berton M. Groves,Janet T. Kernis,Paul S. Levy,Giuseppe G. Pietra,Lynne Reid,John T. Reeves,Stuart Rich,Carol E. Vreim,George W. Williams,Margaret Wu +17 more
TL;DR: Mortality was most closely associated with right ventricular hemodynamic function and can be characterized by means of an equation using three variables: mean pulmonary artery pressure, mean right atrial pressure, and cardiac index.
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