Journal ArticleDOI
The role of inflammatory mediators in chronic heart failure: cytokines, nitric oxide, and endothelin-1
TLDR
The main components which are thought to be relevant to the pathogenesis of CHF are cytokines, adhesion molecules, autoantibodies, nitric oxide, and endothelin-1, and this review will concentrate on these factors.About:
This article is published in International Journal of Cardiology.The article was published on 2000-01-15. It has received 177 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
Citations
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Journal ArticleDOI
Oxidative stress and left ventricular remodelling after myocardial infarction
Masatsugu Hori,Kazuhiko Nishida +1 more
TL;DR: AsK1-deficient mice demonstrate that the ROS/ASK1 pathway is involved in necrotic as well as apoptotic cell death, indicating that ASK1 may be a therapeutic target to reduce left ventricular (LV) remodelling after MI.
Journal ArticleDOI
TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure
TL;DR: The formation and release of TNFalpha and its downstream signal transduction cascade following activation of its two receptor subtypes is characterized, with special emphasis on the cardiovascular system.
OtherDOI
Pathophysiology of Heart Failure.
Edit Tanai,Stefan Frantz +1 more
TL;DR: This summary of the pathophysiology of heart failure tries to give a compact overview of basic mechanisms and of the novel unfolding, progressive theory ofHeart failure to contribute to a more comprehensive knowledge of the disease.
Journal ArticleDOI
How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
TL;DR: High dose anti-TNF therapy may not be useful in CHF patients, but the situation in lower doses and in patients with documented inflammatory/metabolic problems or in cardiac cachexia has not yet been adequately assessed.
Journal ArticleDOI
Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?
TL;DR: The ENABLE study evaluated the effects of low dose bosentan, a non-selective endothelin receptor antagonist, in patients with severe heart failure and appeared to confer an early risk of worsening heart failure necessitating hospitalization, as a consequence of fluid retention.
References
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Journal ArticleDOI
An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
Journal ArticleDOI
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
TL;DR: It is indicated that circulating levels of tumor necrosis factor are increased in cachectic patients with chronic heart failure and that this elevation is associated with the marked activation of the renin-angiotensin system seen in patients with end-stage cardiac disease.
Journal ArticleDOI
Infliximab for the treatment of fistulas in patients with Crohn's disease.
Daniel H. Present,Paul Rutgeerts,Stephan R. Targan,Stephen B. Hanauer,Lloyd Mayer,R. A. van Hogezand,Daniel K. Podolsky,Bruce E. Sands,T. Braakman,K. L. Dewoody,Th.F. Schaible,S. J. H. Van Deventer +11 more
TL;DR: Infliximab is an efficacious treatment for fistulas in patients with Crohn's disease and the most common adverse events for patients treated with infliximab were headache, abscess, upper respiratory tract infection, and fatigue.
Journal ArticleDOI
Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
Michael R. Bristow,Ginsburg R,Minobe W,Cubicciotti Rs,Sageman Ws,Keith G. Lurie,Billingham Me,Harrison Dc,Stinson Eb +8 more
TL;DR: It is concluded that in failing human hearts a decrease in beta-receptor density leads to subsensitivity of the beta-adrenergic pathway and decreased beta-agonist-stimulated muscle contraction.
Journal ArticleDOI
Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study.
Jay N. Cohn,Donald G. Archibald,Susan Ziesche,Joseph A. Franciosa,W. Eugene Harston,Felix E. Tristani,W. Bruce Dunkman,William R. Jacobs,Gary S. Francis,Kathleen H. Flohr,Steven Goldman,Frederick R. Cobb,Pravin M. Shah,Robert S. Saunders,Ross D. Fletcher,Henry S. Loeb,V. Hughes,Bonnie J. Baker +17 more
TL;DR: The data suggest that the addition of hydralazine and isosorbide dinitrate to the therapeutic regimen of digoxin and diuretics in patients with chronic congestive heart failure can have a favorable effect on left ventricular function and mortality.